Neurobiology of Alcohol and Nicotine Co-Addiction (NAUD)

VA Office of Research and Development

Status: Completed

Conditions: Nicotine Use Disorder; Alcohol Use Disorder

Treatments: Behavioral: magnetic resonance imaging (MRI)

Study type: Observational

Funder types: Other; Other U.S. Federal agency

Identifiers

NCT03338933

NURA-002-17S

17321 (Other Identifier)

Details and patient eligibility

About

This proposal addresses the critical absence of information about the neurobiology of recovery from Alcohol Use Disorder (AUD) in alcohol and nicotine users.

Full description

This proposal addresses the critical absence of information about the neurobiology of recovery from Alcohol Use Disorder (AUD) in alcohol and nicotine users. AUD and nicotine use disorder (NUD) are the most commonly abused (non-prescription) substances in the U.S. Co-addiction is particularly high in military veterans. Although nationwide estimates peg the rate of AUD/NUD co-addiction at 80%, the Substance Abuse Treatment Program (SATP) at the Veterans Affairs Portland Health Care System (VAPORHCS) finds that 90% of veterans treated for AUD also meet criteria for NUD. The investigators hypothesize that a support vector machine learning algorithm will be able to use the measures to classify subjects as AUD, NUD both or neither and that the algorithm will predict outcome (sobriety or relapse) at three months.

Enrollment: 109 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• None

Exclusion criteria

• None

Trial design

109 participants in 4 patient groups

Control Group

Description:

No history of addiction to any substance or gambling. Less than 20 lifetime cigarettes or equivalent.

Treatment:

Behavioral: magnetic resonance imaging (MRI)

Nicotine Group

Description:

Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-V) criteria for Nicotine Use Disorder. Current smoker, at least 10 cigarettes per day. No history of addiction to any other substance

Treatment:

Behavioral: magnetic resonance imaging (MRI)

Nicotine and Alcohol Group

Description:

DSM-V criteria for Nicotine Use Disorder and Alcohol Use Disorder. At least 8 heavy drinking episodes in the past month. Current smoker. Alcohol free from 2 to 4 weeks. No history of addiction to other substances or gambling.

Treatment:

Behavioral: magnetic resonance imaging (MRI)

Alcohol Group

Description:

DSM-V criteria for Alcohol use Disorder. At least 8 heavy drinking episodes in the past month. Abstinent for at least 2 weeks and no more than 4 weeks. Less than 20 lifetime cigarettes or equivalent. No history of addiction to any other substances or gambling.

Treatment:

Behavioral: magnetic resonance imaging (MRI)