Neurobiomarker for Prism Adaptation Treatment Response

Utah System of Higher Education (USHE)

Status: Withdrawn

Conditions: Perceptual Disorders; Stroke; Biomarker

Treatments: Behavioral: Prism Adaptation Therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT04966000

IRB_00140741

Details and patient eligibility

About

Preliminary data will be collected about which individuals with spatial neglect from right hemisphere stroke (aiming vs perceptual neglect) improve with Prism Adaptation Training and if there is a particular pattern of damage in the brain that predicts both the type of neglect experienced and whether neglect is improved following Prism Adaptation Training

Full description

For preliminary data, twelve individuals with right hemisphere stroke and spatial neglect will participate. After pretesting for type of neglect and its severity, they will have an MRI with Diffusion Tensor Imaging (DTI). Then they will complete 10 sessions of Prism Adaptation Therapy and complete neglect post-testing. Response to Prism Adaptation Therapy will be assessed by comparing neglect scores pre- and post-training. Traditional lesion mapping, structural and functional lesion disconnectivity analyses, and tract-based spatial statistics of DTI measures will be used to examine whether any patterns of damage/dysfunction are related to a diagnosis of aiming neglect and response to Prism Adaptation Therapy.

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 1. within 1 month of right hemisphere stroke

  2. suspected of having unilateral spatial neglect

  3. able to provide consent

  4. likely to remain in rehabilitation for 10-12 days or willing to return to the University to complete 10 sessions of treatment and post-treatment testing

  5. able to have an MRI

  6. will be or has been admitted to the Craig H. Neilson Rehabilitation Hospital for rehabilitation or is able to come to the Craig H. Neilson Rehabilitation Hospital for prism adaptation therapy sessions.

  7. age 18-90 years

  8. able to sit in a wheelchair or other chair for 1 hour

  9. able to point straight ahead and hold a pen with right hand

Exclusion criteria

• 1. other neurologic, medical that would interfere with ability to complete the testing or training

  2. no uncorrected visual or hearing problems, other than hemianopsia

  3. contraindications to MRI

  4. unable to provide consent due to significant aphasia or cognitive impairment

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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0 participants in 1 patient group

Prism Adaptation Therapy

Experimental group

Description:

10 sessions (60 trials each) 1x/day of Prism Adaptation Therapy

Treatment:

Behavioral: Prism Adaptation Therapy