Neurocognitive Effects of Meal Timing in a One-Meal-a-Day Regimen (OMAD)

Erzurum Technical University

Status: Completed

Conditions: Fasting State; Cognitive Abilities

Treatments: Other: one-meal-a-day (OMAD)

Study type: Interventional

Funder types: Other

Identifiers

NCT07181057

ETU-OMAD-2025-01

Details and patient eligibility

About

Objectives: The purpose of this study is to examine how meal timing in a one-meal-a-day (OMAD) regimen influences neurocognitive outcomes.

Methods: Twelve cognitively active participants (academics, students, software engineers) will complete three randomized OMAD conditions, consuming a standardized isocaloric meal at 08:00, 12:30, or 18:00. ERPs will be recorded during a computerized Stroop task to evaluate peak amplitudes and latencies under congruent and incongruent conditions. Resting-state EEG will be measured under eyes-open and eyes-closed conditions. Behavioral performance on the Stroop task, including reaction time and accuracy, will also be assessed.

Enrollment: 12 patients

Sex: Male

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Male, 20 to 45 years of age

Right-handed

Normal or corrected-to-normal vision

Cognitively active individuals (academic staff, graduate students, or software/algorithm engineers)

Regular sleep-wake schedule during the week preceding the experiment

Ability to abstain from caffeine, alcohol, or psychoactive substances for at least 24 hours prior to each test session

Body mass index between 18.5 and 30 kg/m²

Exclusion criteria

History of neurological, psychiatric, metabolic, or sleep disorders

Current use of medications that affect the central nervous system

Shift work or irregular sleep patterns (verified by sleep diary)

Prior experience with one-meal-a-day dietary routines

Body mass index below 18.5 or above 30 kg/m²

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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12 participants in 1 patient group

Single Group (Crossover)

Experimental group

Description:

Arm Title: Morning Meal (08:00) Arm Type: Experimental Intervention: Other: One-meal-a-day (OMAD) Arm Description: Participants consume a single standardized isocaloric meal at 08:00. Neurocognitive outcomes (ERP, resting-state EEG, Stroop performance) are assessed during morning (before meal) and afternoon (approximately 6 hours post-meal) sessions. Arm Title: Midday Meal (12:30) Arm Type: Experimental Intervention: Other: One-meal-a-day (OMAD) Arm Description: Participants consume a single standardized isocaloric meal at 12:30. Neurocognitive outcomes (ERP, resting-state EEG, Stroop performance) are assessed during morning (before meal) and afternoon (approximately 6 hours post-meal) sessions. Arm Title: Evening Meal (18:00) Arm Type: Experimental Intervention: Other: One-meal-a-day (OMAD) Arm Description: Participants consume a single standardized isocaloric meal at 18:00. Neurocognitive outcomes (ERP, resting-state EEG, Stroop performance) are assessed during morning (before mea

Treatment:

Other: one-meal-a-day (OMAD)