Neurocognitive Impairment and Psychiatric Comorbidities in HIV-1

The HIV Netherlands Australia Thailand Research Collaboration

Status: Completed

Conditions: HIV Infections

Treatments: Procedure: lumbar puncture, MRI, MRS

Study type: Observational

Funder types: Other

Identifiers

NCT00476671

HIV-NAT 040

Details and patient eligibility

About

To assess the prevalence and risk factors of neurocognitive impairment and psychiatric comorbidities in HIV infected patients who have undetectable viral load, have been on HAART for at least 1 year and have no history of CNS infection.

Full description

To understand how to prevent and treat HIV-associated neurocognitive impairment and psychiatric comorbidities in HIV-infected Thai individuals who don't have current AIDS related illness or current and prior central nervous system (CNS) infection, and have been well treated with HAART with undetectable HIV RNA.

Enrollment: 100 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Signed informed consent
• Evidence of HIV infection (confirmed positive ELISA and documented history of measurable HIV RNA)
• Age > 18 years old
• Plasma HIV RNA of < 50 copies/ml within 3 months prior to screening
• Have been on only NNRTI-based HAART regimen for the entire duration and for at least1 year.

Exclusion criteria

• Current AIDS defining illnesses
• Current or history of previous CNS infection.
• Head injury with loss of consciousness greater than 1 hour
• Acute illness within 30 days prior to entry that, in the opinion of investigators, would prevent patients from completing the protocol required procedures.
• Known learning disability including dyslexia

Trial design

100 participants in 1 patient group

1

Description:

HIV infected adults with viral load \< 50 copies/ml on NNRTI based HAART

Treatment:

Procedure: lumbar puncture, MRI, MRS