NEURodevelopmental Outcome After Persistent Pulmonary Hypertension Of the Newborn (NEUROPHON)

Toulouse University Hospital

Status: Completed

Conditions: Persistent Pulmonary Hypertension of the Newborn

Treatments: Other: Ages & Stages Questionnaires®, Third Edition (ASQ3)

Study type: Interventional

Funder types: Other

Identifiers

NCT04841070

RC31/21/0186

Details and patient eligibility

About

Neonatal pulmonary hypertension is a rare but serious condition resulting from a lack of adaptation to extra-uterine life in some newborns. In the short term, the risk of death requires rapid and appropriate management of this transient pathology.

In the long term, these newborns present a greater brain vulnerability, a consequence of the pathology itself with cerebral hypoxia but also invasive and aggressive therapies. Although current scientific evidence indicates a correlation with the existence of neurological developmental disorders, the understanding of the long-term neurological outcome of these babies remains poorly documented. Better knowledge of remote neuro-psychomotor development of the critical period

Enrollment: 55 patients

Sex: All

Ages: 1 to 5 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All parenting authority holders of children aged 1 to 5 years, born after 34 weeks of amenorrhea and having been cared for neonatal PAH in paediatric resuscitation

Exclusion criteria

• Holders of parental authority who cannot answer the questionnaire because they do not speak French.
• Opposition of one of the two holders of parental authority
• Minor parental authority holders
• Holders of parental authority under safeguarding of justice, guardianship or guardianship
• Newborns with neonatal PAH with an associated diagnosis of diaphragmatic hernia or cyanogenic congenital heart disease
• Newborns with neonatal PAH not treated with nitrogen monoxide

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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55 participants in 1 patient group

Persistent pulmonary hypertension of the newborn.

Experimental group

Description:

Children aged 1 to 5 years who have been hospitalized in pediatric resuscitation service for the treatment of persistent pulmonary hypertension of the newborn.

Treatment:

Other: Ages & Stages Questionnaires®, Third Edition (ASQ3)