Neurofeedback Based on Near-infrared Spectroscopy as a Therapy for Food Addiction in Obese Subjects. (CaDOb)

Rennes University Hospital

Status

Enrolling

Conditions

Craving

Obesity

Treatments

Other: NF

Other: Sham

Study type

Interventional

Funder types

Other

Identifiers

NCT05277714

35RC21_8946_08_CadOb

Details and patient eligibility

About

The hypothesis is that the increase in dlPFC brain activity via near-infrared spectroscopy-based Neurofeedback (fNIRS-based NF) training based on near-infrared spectroscopy would allow an improvement of the eating behavior, thus promoting a long-term weight loss in obese subjects.

Patients will be trained during a month with 8 NF sessions and results based on clinical data and different questionnaires results will be compared between inclusion and 3 months later

Full description

Obesity is a disease of increasing prevalence due in part to the greater availability of fatty, sugary and/or salty foods which, when consumed chronically and in excess, can lead to food addiction.

According to the neurocognitive model of addiction, the development and maintenance of addiction is associated with deficits in cognitive control, as well as a decrease prefrontal cortex (dlPFC). Self-control in food choice situations also depends on prefrontal network with the dlPFC as a hub, strongly connected with striatal and cingulate structures.

Neurofeedback (NF) is a technique that relies on the patient's positive or negative self-regulation of brain activity. It has been shown to be effective in several pathologies, in particular attention deficit/hyperactivity disorder in young people and more recently in depression and emotion regulation.

In this study, NF will be based on near-infrared spectroscopy (fNIRS), because its use is easy mobile and inexpensive. The hypothesis is that the increase in dlPFC brain activity via fNIR-based NF training based on fNIRS would allow an improvement of the eating behavior, thus promoting a long-term weight loss in obese subjects.

Enrollment

50 estimated patients

Sex

Female

Ages

18 to 55 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Eligible for obesity surgery according to the 2009 French High Authority on Health (HAS) criteria (BMI ≥40 or BMI ≥35 with comorbidities)
Right-handed
Presenting a food addiction determined by the YFAS 2.0 questionnaire ;
Affiliated to a social security system;
Having given free and informed consent in writing.

Exclusion criteria

Psychotic psychiatric disorders (schizophrenic disorders and bipolar disorders);
Psychotropic drugs, except antidepressants stabilized for at least 3 weeks and benzodiazepines
Addiction to alcohol or other psychoactive substances (except tobacco);
History of bariatric surgery;
Current treatment in the nutrition unit;
Insufficient command of French;
Pregnant or breast-feeding woman;
Persons of legal age under legal protection (safeguard of justice, curatorship, guardianship), persons deprived of liberty.
Contraindications to fMRI
Inability to perform the fNIRS procedure due to blockage or attenuation of the light at the capillary level