Neurofeedback Training for Older Adults With Mild Cognitive Impairment: a Protocol Study

F

Fabienne Marlats

Status

Unknown

Conditions

Mild Cognitive Impairment

Treatments

Behavioral: Neurofeedback

Study type

Interventional

Funder types

Other

Identifiers

NCT03526692
LUS1EEGNF

Details and patient eligibility

About

This is a non-pharmacological study evaluating the effects of SMR/delta ratio and beta1/theta ratio neurofeedback trainings on cognitive performance and electrical brain activity in elderly with mild cognitive impairment.

Full description

Older adults with Mild Cognitive Impairment (MCI) are at high risk to progress to Alzheimer's disease (AD). Slowing down effect of dementia by enhancing brain plasticity represents one of the most prominent challenges. Neurofeedback is one of the promising techniques that showed therapeutic efficacy and cognitive improvement in attention-deficit hyperactivity disorder, epilepsy, stroke. We aim to study the effects of two neurofeedback training protocols, SMR/delta ratio and beta1/theta ratio, on cognitive performances in older adults with Mild Cognitive Impairment and to assess whether MCI patients change in brain electrical activity in a resting state after training.

Enrollment

60 estimated patients

Sex

All

Ages

60+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Clinical diagnosis of Mild Cognitive Impairment
  • MMSE score >24
  • Subjective memory complaint confirmed by an informant.
  • Perform at/or below 1.5 standard deviations from the mean for age and education-matched norms on more than one of the neuropsychological tests.
  • Preserve activity of daily living
  • Absence of dementia.

Exclusion criteria

  • Psychiatric and neurological disorders
  • History of alcohol or other substance consumption

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

60 participants in 3 patient groups

Sensorimotor/delta NF training group
Experimental group
Description:
Three interventions will be administered: An electroencephalography recording (EEG) for 30 minutes.We will use an electrocap of 19 scalp locations according to the International 10-20 EEG placement system. The second intervention is the neuropsychological assessments and questionnaires. They will be done in one session for approximately 2 hours. The third intervention is the neurofeedback training sensorimotor/delta ratio that will be recorded at channel Cz according to the International 10-20 system.
Treatment:
Behavioral: Neurofeedback
Beta1/theta NF training group
Experimental group
Description:
Three interventions will be administered: An electroencephalography recording (EEG) for 30 minutes.We will use an electrocap of 19 scalp locations according to the International 10-20 EEG placement system. The second intervention is the neuropsychological assessments and questionnaires. They will be done in one session for approximately 2 hours. The third intervention is the neurofeedback training Beta1/theta ratio that will be recorded at channel Fz according to the International 10-20 system.
Treatment:
Behavioral: Neurofeedback
Control group
No Intervention group
Description:
Three interventions will be administered: An electroencephalography recording for 30 minutes.We will use an electrocap of 19 scalp locations according to the International 10-20 EEG placement system. The second intervention is the neuropsychological assessments and questionnaires. They will be done in one session for approximately 2 hours. The psychopedagogical care : Each session will be organized using the same video material than for the NF training sessions.

Trial contacts and locations

0

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Central trial contact

Anne-Sophie AR Rigaud, professor; Fabienne FM Marlats, PhD candidate

Data sourced from clinicaltrials.gov

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