Neurofeedback Training for Older Adults With Mild Cognitive Impairment: a Protocol Study

Fabienne Marlats

Status: Unknown

Conditions: Mild Cognitive Impairment

Treatments: Behavioral: Neurofeedback

Study type: Interventional

Funder types: Other

Identifiers

NCT03526692

LUS1EEGNF

Details and patient eligibility

About

This is a non-pharmacological study evaluating the effects of SMR/delta ratio and beta1/theta ratio neurofeedback trainings on cognitive performance and electrical brain activity in elderly with mild cognitive impairment.

Full description

Older adults with Mild Cognitive Impairment (MCI) are at high risk to progress to Alzheimer's disease (AD). Slowing down effect of dementia by enhancing brain plasticity represents one of the most prominent challenges. Neurofeedback is one of the promising techniques that showed therapeutic efficacy and cognitive improvement in attention-deficit hyperactivity disorder, epilepsy, stroke. We aim to study the effects of two neurofeedback training protocols, SMR/delta ratio and beta1/theta ratio, on cognitive performances in older adults with Mild Cognitive Impairment and to assess whether MCI patients change in brain electrical activity in a resting state after training.

Enrollment: 60 estimated patients

Sex: All

Ages: 60+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of Mild Cognitive Impairment
• MMSE score >24
• Subjective memory complaint confirmed by an informant.
• Perform at/or below 1.5 standard deviations from the mean for age and education-matched norms on more than one of the neuropsychological tests.
• Preserve activity of daily living
• Absence of dementia.

Exclusion criteria

• Psychiatric and neurological disorders
• History of alcohol or other substance consumption

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 3 patient groups

Sensorimotor/delta NF training group

Experimental group

Description:

Three interventions will be administered: An electroencephalography recording (EEG) for 30 minutes.We will use an electrocap of 19 scalp locations according to the International 10-20 EEG placement system. The second intervention is the neuropsychological assessments and questionnaires. They will be done in one session for approximately 2 hours. The third intervention is the neurofeedback training sensorimotor/delta ratio that will be recorded at channel Cz according to the International 10-20 system.

Treatment:

Behavioral: Neurofeedback

Beta1/theta NF training group

Experimental group

Description:

Three interventions will be administered: An electroencephalography recording (EEG) for 30 minutes.We will use an electrocap of 19 scalp locations according to the International 10-20 EEG placement system. The second intervention is the neuropsychological assessments and questionnaires. They will be done in one session for approximately 2 hours. The third intervention is the neurofeedback training Beta1/theta ratio that will be recorded at channel Fz according to the International 10-20 system.

Treatment:

Behavioral: Neurofeedback

Control group

No Intervention group

Description:

Three interventions will be administered: An electroencephalography recording for 30 minutes.We will use an electrocap of 19 scalp locations according to the International 10-20 EEG placement system. The second intervention is the neuropsychological assessments and questionnaires. They will be done in one session for approximately 2 hours. The psychopedagogical care : Each session will be organized using the same video material than for the NF training sessions.