Neuroimaging Studies of Smoking and Treatment

University of Kansas

Status: Completed

Conditions: Smoking Cessation

Treatments: Behavioral: Cognitive behavioral therapy; Behavioral: Health education

Study type: Interventional

Funder types: Other

Identifiers

NCT03085602

STUDY00001782

Details and patient eligibility

About

The purpose of this research study is to examine changes in brain regions associated with cognitive control and reward processing during behavioral smoking cessation treatment.

Enrollment: 92 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• smoke > 10 cigarettes per day
• vision is normal or corrected-to-normal

Exclusion criteria

• serious medical illness unsuitable for the MR scanner based on best clinical judgment
• any neurologic or psychiatric disorder
• diabetes
• known heart disease
• high blood pressure
• currently taking psychotropic or cardiovascular medication
• history of alcohol or other substance dependence or current abuse
• risk for hazard due to magnetic fields such as metal in the body surgically or accidentally (e.g., pacemaker, cochlear implants, aneurysm clips, intravascular stents or coils, spinal shunt, injury involving bullets, shrapnel or metal implanted in their body, etc)
• pregnancy

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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92 participants in 3 patient groups

CBT Treatment

Experimental group

Description:

Participants receive Cognitive behavioral therapy (CBT). Participants will receive 4 one hour CBT treatments.

Treatment:

Behavioral: Cognitive behavioral therapy

Control Group

Active Comparator group

Description:

Participants receive health education treatment. Participants will attend treatment sessions that match the CBT Treatment arm with respect to time and contact.

Treatment:

Behavioral: Health education

Control Group - Scans

No Intervention group

Description:

Participants in this new arm to the study will receive no intervention and will receive three scans.