Neuroimaging Study of Factors Related to Exercise

University of Kansas

Status

Completed

Conditions

Obesity

Treatments

Other: Exercise

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT02010463

5R01DK085605 (U.S. NIH Grant/Contract)

5R01DK085605-04

Details and patient eligibility

About

This study aims to support the hypothesis that brain processes underlying reward processing and impulse control contribute to obesity and to adherence in a new exercise regimen.

Full description

This is a nonrandomized trial with groups being defined by BMI and adherence status to the exercise intervention.

Enrollment

200 estimated patients

Sex

All

Ages

18 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

BMI >25 to < 40±1
Must live in the Greater Kansas City area for at least 1 year
Willing to exercise
Provide written approval from a licensed physician that they are healthy enough to participate in a program of moderate physical activity and maximum O2 testing
All participants must be sedentary except for casual recreation such as softball, bowling, etc.

Exclusion criteria

Color-blindness
Left-handedness
Any diagnosed neurological disorder or conditions that preclude MRI scanning (e.g., metal in body)
Participation in a research project involving weight loss or physical activity in the previous 6 months
Subjects who smoke
Subjects use medications that affect metabolism (i.e. thyroid, beta blockers), use medications that affect appetite (i.e. Meridia) or cannot exercise (i.e. walk)
Participants will be excluded by study personnel following interview if they exhibit eating disorders, binge eating, depression or drug addiction
Metabolic disease that would affect energy balance (e.g. diabetes mellitus or hypothyroidism)
Pregnant during the previous 6 months, are lactating, or plan pregnancy within 12 months
Individuals who are not weight stable (± 4.5kg) within the previous year.
Serious medical risks such as type 1-diabetes, cancer, recent cardiac event (i.e. heart attack, angioplasty, etc.)
High blood pressure
Current use of smoking/tobacco products or initiation of the use of smoking/tobacco products during the study and alcohol abuse and any history of dependence
Subject IQ is less that 80
Reported radiation exposure from CT, PET, fluoroscopic or nuclear medicine studies within the previous year, or other radiation exposure at the discretion of the PI