Neuroinflammation/Oxidative Stress/Cardiac Surgery (NEuOX-postSURg)

Europainclinics z.ú.

Status: Enrolling

Conditions: Neuroinflammation

Treatments: Other: extracorporeal circulation

Study type: Observational

Funder types: Other

Identifiers

NCT06391866

NeuOX-postSurg Trial

Details and patient eligibility

About

The prospective observational study delves into the complex relationship between neuroinflammation and oxidative stress in post-cardiac surgery complications, focusing on postoperative cognitive dysfunction.

Full description

The prospective observational study meticulously examines the interplay between neuroinflammation and oxidative stress in the realm of post-cardiac surgery complications, specifically targeting postoperative cognitive dysfunction. Its primary objective is to comprehensively assess the sustained influence of these intricate processes on cognitive function and overall well-being, extending beyond the immediate aftermath of surgery. The research endeavors to probe deeply into the molecular mechanisms and clinical ramifications associated with neuroinflammation and oxidative stress, centering on their pivotal role in shaping the onset and trajectory of postoperative cognitive dysfunction.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Undergoing cardiosurgical operation
• Absence of previous neurological disease
• Signed informed consent document

Exclusion criteria

• Presence of neoplasms
• Neurological Disease
• Refusal to participate in the clinical trial

Trial design

60 participants in 3 patient groups

Experimental group 1

Description:

Patients scheduled for elective cardiac surgery, such as coronary artery bypass grafting (CABG) or valve replacement, involving extracorporeal circulation (ECC) with a duration less than 60 minutes.

Treatment:

Other: extracorporeal circulation

Experimental group 2

Description:

Patients undergoing scheduled cardiac procedures, including coronary artery bypass grafting (CABG) or valve replacement, requiring extracorporeal circulation (ECC) for more than 60 minutes.

Treatment:

Other: extracorporeal circulation

Control group:

Description:

Patients scheduled for cardiac surgical procedures such as coronary artery bypass grafting (CABG) without extracorporeal circulation, and for carotid endarterectomy in neurologically asymptomatic patients prior to the procedure.