Neurological Blood-based Biomarkers and Cognitive Disorders in Critically Ill Survivors. (COGNISI)

University of Liege

Status: Enrolling

Conditions: Cognitive Disorder; Post-intensive Care Syndrome; Intensive Care Unit Syndrome

Treatments: Other: Blood analysis; Other: Cognitive tests

Study type: Observational

Funder types: Other

Identifiers

NCT05953311

COGNISI

Details and patient eligibility

About

Cognitive disorders are common after intensive care. Currently, their diagnosis is based on clinical tests. The investigators plan to study the relationship between different neurological blood biomarkers (cytokines, S100β protein, neuron specific enolase, total Tau protein and neurofilament light chain) and the occurrence of cognitive disorders during the three months following intensive care discharge.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Anticipated ICU stay of at least 7 days for sepsis, acute respiratory distress syndrome, severe burns
• French speaking

Exclusion criteria

• hearing loss or blindness
• mental retardation
• known cognitive disorders or dementia
• ICU admission for neurological disease
• refusal

Trial design

30 participants in 1 patient group

ICU survivors

Description:

Cohort of patients who survive an ICU stay of at least 7 days

Treatment:

Other: Cognitive tests

Other: Blood analysis