Neurological Effects of Chemotherapy and Radiation Therapy in Patients With Colon Cancer

University of Arizona

Status: Completed

Conditions: Long-term Effects Secondary to Cancer Therapy in Adults; Cognitive/Functional Effects; Colorectal Cancer

Treatments: Procedure: magnetic resonance imaging; Procedure: cognitive assessment; Procedure: management of therapy complications

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00410618

UARIZ-BSC-02-13 (Other Identifier)

P30CA023074 (U.S. NIH Grant/Contract)

HSCB0213

P50CA095060 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

RATIONALE: Learning about the long-term effects of chemotherapy and radiation therapy on brain function may help doctors plan cancer treatments.

PURPOSE: This clinical trial is looking at the neurological effects of chemotherapy and radiation therapy in patients with colon cancer.

Full description

OBJECTIVES:

Primary

• Identify the nature and long-term ramifications of CNS injury as a result of cancer treatment in patients with colon cancer.

Secondary

• Analyze differences in cognitive measures and MRI data in these patients.
• Correlate MRI measures with cognitive performance in these patients.

OUTLINE: Patients undergo cognitive performance assessment and MRI.

PROJECTED ACCRUAL: A total of 42 patients will be accrued for this study.

Enrollment: 42 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

• Diagnosis of colon cancer
• Received chemotherapy and radiotherapy for colon cancer

PATIENT CHARACTERISTICS:

• Not specified

PRIOR CONCURRENT THERAPY:

• See Disease Characteristics