Neurological Effects of Goal-directed Fluid Therapy in Beach Chair Position Shoulder Surgery

National Taiwan University

Status: Completed

Conditions: Anesthesia; Postoperative Cognitive Dysfunction

Treatments: Procedure: Non goal-directed fluid therapy; Procedure: Goal-directed fluid therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT03963063

201903017RINB

Details and patient eligibility

About

Patients receiving beach chair position shoulder surgery are vulnerable to perioperative cerebral desaturation, which is reported to be a risk factor for postoperative cognitive dysfunction. Investigators design this study to test the efficacy of perioperative goal-directed therapy in preventing cerebral desaturation and postoperative cognitive dysfunction in patients receiving beach chair position shoulder surgery.

Enrollment: 70 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients receiving scheduled beach chair position shoulder surgery

Exclusion criteria

• pregnant women
• patients in intensive care units
• patients with respiratory failure [forced expiratory volume at one second (FEV1)/ forced vital capacity (FVC) < 70 % and FEV1 < 50%]
• patients with heart failure(NYHA score =III、IV)
• patients with chronic kidney disease (eGFR< 60 ml.min-1.1.73m-2)
• patients with liver failure
• patients with ongoing infection
• patients allergic to voluven

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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70 participants in 2 patient groups

Non Goal-directed Care Group

Active Comparator group

Treatment:

Procedure: Non goal-directed fluid therapy

Goal-directed Care Group

Experimental group

Treatment:

Procedure: Goal-directed fluid therapy