Neurological Impacts of Artificial Sweeteners in the Context of Diet Sodas

Beth Israel Lahey Health

Status: Completed

Conditions: Obesity

Treatments: Behavioral: Carbonated Water; Behavioral: Regular soda; Behavioral: diet soda

Study type: Interventional

Funder types: Other

Identifiers

NCT04048681

2019P000649

Details and patient eligibility

About

This study seeks to determine whether artificial sweeteners in the context of diet soda may alter the brain's response to food cues and thus impact appetite.

Enrollment: 5 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Men and women who are 18-65 years old, with a BMI >30kg/m2.

Exclusion criteria

• Unable or unwilling to participate in the study for any reason
• Metal in the body or other safety concerns which makes patient unable to have an MRI
• Pregnant women will be excluded to protect the fetus against potential effects of a non-medically required MRI on fetal development and difficulty of measuring accurate BMI.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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5 participants in 3 patient groups, including a placebo group

Diet Soda

Experimental group

Description:

12oz can of Diet Coke

Treatment:

Behavioral: diet soda

Soda

Active Comparator group

Description:

12oz can of Coke

Treatment:

Behavioral: Regular soda

Carbonated Water

Placebo Comparator group

Description:

12oz can of carbonated (unflavored) water

Treatment:

Behavioral: Carbonated Water