Neurological Symptoms and Findings in Individuals Exposed to Indoor Air Pollutants

Turku University Hospital (TYKS)

Status

Completed

Conditions

Exposure to Polluted Air

Study type

Observational

Funder types

Other

Identifiers

NCT05111678

1/2021

Details and patient eligibility

About

To evaluate neurological findings with TSPO-PET and MRI in patients who have been exposed to indoor air pollutants and have potentially neurological symptoms.

Full description

Health problems related to indoor air pollutants have been studied for several decades but there is still not sufficient scientific evidence to prove the association between many of the described symptoms and exposure to mold and other air pollutants.

This research aims on studying the activation of microglia and inflammation in the brains of individuals exposed to indoor air pollutants having neurological symptoms with MRI and TSPO-PET imaging, questionnaires and biomarkers and compare the findings to individuals having neurological conditions without exposure to indoor air pollutants as well as healthy controls.

Enrollment

35 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

All:

Signing the informed consent form
Adults over 18 years of age

Indoor air pollutant groups:

Exposed to indoor air pollutants
Neurological symptoms

Neurological symptoms groups:

Neurological symptoms possibly due to adverse external exposure

Healthy controls:

Reported healthy person

Exclusion criteria

All:

Pregnancy or breast-feeding
Corticosteroid treatment within 4 weeks of imaging
Patients with claustrophobia, or a history of moderate to severe anxiety disorder or panic attacks (which could potentially lead to preterm termination of the imaging)
Contraindication to PET scan and MRI investigations
Exposure to experimental radiation in the past 12 months such that radiodosimetry limits would be exceeded by participating in this study.
Intolerance to previous PET scans; i.e. previous hypersensitivity reactions to any PET ligand or imaging agent or failure to participate in and comply with previous PET scans.

Neurological symptoms groups and healthy controls: