Neuromarker S-100B as Diagnostic Tool (SpineSurgery)

Medical University of Vienna

Status: Completed

Conditions: Spinal Injury

Study type: Observational

Funder types: Other

Identifiers

NCT01840397

Wolf-6

Details and patient eligibility

About

The hypothesis of this study is to find evidence if there is an influence of spine surgery on the serum levels of two proteins secreted from neuronal cells.

Full description

The question, if there is an effect on the cerebrospinal system during spine surgery, which can be traced by monitoring serum levels of neuromarkers is not yet answered. This study has its background from other studies on patients with traumatic brain injury (TBI), in whom elevated serum levels of the two neuromarkers S-100B and NSE are associated with injury severity, neuronal damage, brain, tissue damage, and outcome. Patients undergoing spine surgery with or without pre-existing traumatic neurologic symptoms are planned to be the study cohort. Pre- and postoperatively the serum levels of S-100B and NSE are obtained and are statistically compared with patients undergoing other types of bone-related surgery.

Enrollment: 30 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• spine fracture

Exclusion criteria

• additional traumatic brain injury
• fractures of the long bones
• polytrauma
• severely injured patients

Trial design

30 participants in 2 patient groups

Spine surgery

Description:

Patients undergoing spine surgery

Bone surgery

Description:

Patients undergoing bone surgery for fracture treatment other than spine fractures