Neuromas as the Cause of Pain

Danish Pain Research Center

Status: Completed

Conditions: Neuropathic Pain; Neuroma

Treatments: Drug: Lidocaine; Drug: Isotonic Saline

Study type: Interventional

Funder types: Other

Identifiers

NCT02930551

Neurom2016

Details and patient eligibility

About

Neuromas are frequent after trauma and surgery, including amputation and can be identified by high-resolution ultrasound. The role of neuromas as the cause of neuropathic pain is uncertain. The investigators therefore wish to explore if spontaneous and evoked pain will be relieved by injection of local anesthetics near painful neuromas in subjects with peripheral nerve injury.

Enrollment: 12 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Subjects with peripheral nerve injury 3 months prior to participation

Exclusion criteria

• Severe somatic or psychiatric diseases
• Other peripheral neuropathy
• Lack of ability to cooperate to the clinical examination
• Allergy to Lidocaine or similar analgetics

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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12 participants in 2 patient groups, including a placebo group

Lidocaine

Active Comparator group

Description:

Lidocaine 2 ml injection with 2% Adrenaline

Treatment:

Drug: Lidocaine

Isotonic Saline

Placebo Comparator group

Description:

Isotonic Saline 2 ml Injection

Treatment:

Drug: Isotonic Saline