Neuromodulation of Conscious Perception: Investigating Thalamic Roles Through Ultrasonic Stimulation

University of Michigan

Status: Completed

Conditions: Thalamus

Treatments: Device: LIFUP inhibition; Device: LIFUP excitation

Study type: Interventional

Funder types: Other

Identifiers

NCT06083493

HUM00240514

Details and patient eligibility

About

The purpose of this study is to evaluate the role that the thalamus (the egg-shaped structure in the middle of your brain) plays in perception using a low-intensity ultrasound pulsation (LIFUP) device. The researchers expect to observe differential changes in the perceptual outcomes based on the LIFUP stimulation of different thalamic areas

Enrollment: 61 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Must be right-handed.
• Must have normal or corrected-to-normal vision (while wearing contact lenses). Please note: persons who need eyeglasses to achieve 20/20 vision cannot be included in this study as eyeglasses cannot be worn during the study visit.
• Must not be on any medications for any neurological, psychological, or psychiatric conditions.
• Must be English speaking.
• Must be capable of giving written informed consent.

Exclusion criteria

• Vision that is not 20/20, or vision that is not corrected to 20/20 while wearing contact lenses.

Please note: persons needing eyeglasses to achieve 20/20 vision cannot be included in this study as eyeglasses cannot be worn during the study visit.

• History of significant head injury with loss of consciousness.
• Learning disability or other developmental disorder.
• Medication use for any neurological, psychological, or psychiatric conditions.
• Any impairment (sensory or motor loss), activity, or situation that in the judgment of the study coordinator or Principal Investigators would prevent satisfactory completion of the study protocol.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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61 participants in 2 patient groups

LIFUP excitation

Experimental group

Description:

The study will involve the enrollment of 60 participants, who will be randomly assigned to two groups, with each group consisting of 30 participants. The participants will be divided based on the type of transcranial LIFUP they will receive, either excitation or inhibition, targeting four specific thalamic areas.

Treatment:

Device: LIFUP excitation

LIFUP inhibition

Experimental group

Description:

The study will involve the enrollment of 60 participants, who will be randomly assigned to two groups, with each group consisting of 30 participants. The participants will be divided based on the type of transcranial LIFUP they will receive, either excitation or inhibition, targeting four specific thalamic areas.

Treatment:

Device: LIFUP inhibition