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Neuromodulation Techniques in the Treatment of Chronic Tinnitus With Hearing Loss

U

University of Brasilia

Status

Completed

Conditions

Hearing Loss
Tinnitus

Treatments

Procedure: Transcranial Magnetic Stimulation
Procedure: Transcranial Direct Current Stimulation

Study type

Interventional

Funder types

Other

Identifiers

NCT01944501
CFSNCC2013 (Other Grant/Funding Number)

Details and patient eligibility

About

This study aimed at trying transcranial magnetic stimulation and transcranial direct current stimulation as potential treatments to decrease tinnitus in patients with significant hearing loss.

Full description

Tinnitus is a very common condition and affects approximately 15% of the population, disrupting sleep, emotional balance and social life of the patients. Acoustic deprivation causes hearing loss and is responsible for a cascade of processes that result in the reorganization of the cortex through a synchronization of neuronal activity related to a cortical re-mapping. Consistent with the hypothesis that tinnitus is caused by abnormal activation of the auditory cortex, repetitive transcranial magnetic stimulation (rTMS) can temporarily reduce cortical hyperactivity through direct neuromodulation of the temporal cortex. Furthermore, studies have shown that transcranial direct current stimulation (tDCS) can also suppress tinnitus. Objective: To determine the effectiveness of rTMS and TDCS in the treatment of patients with chronic tinnitus and auditory loss. Methods: We performed an analytical experimental double-blind study using rTMS and tDCS in patients with chronic tinnitus and hearing loss.

Enrollment

36 patients

Sex

All

Ages

45 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • chronic tinnitus
  • hearing loss

Exclusion criteria

  • neurological diseases
  • use of drugs affecting the central nervous system
  • evidence of dementia
  • clinical diagnosis of depression

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

36 participants in 4 patient groups, including a placebo group

Transcranial Magnetic Stimulation
Active Comparator group
Description:
Patients receiving real transcranial magnetic stimulation
Treatment:
Procedure: Transcranial Magnetic Stimulation
Sham TMS
Placebo Comparator group
Description:
Patients receiving sham transcranial magnetic stimulation
Treatment:
Procedure: Transcranial Magnetic Stimulation
Transcranial Direct Current Stimulation
Active Comparator group
Description:
Patients receiving real transcranial direct current stimulation
Treatment:
Procedure: Transcranial Direct Current Stimulation
Sham TDCS
Placebo Comparator group
Description:
Patients receiving sham transcranial direct current stimulation
Treatment:
Procedure: Transcranial Direct Current Stimulation

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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