Neuromuscular Blocking Agents Utilized During Perioperative Hypersensitivity Evaluation

Mayo Clinic

Status: Completed

Conditions: Allergy

Treatments: Diagnostic Test: Skin Testing

Study type: Interventional

Funder types: Other

Identifiers

NCT04046731

18-007462

Details and patient eligibility

About

The researchers are trying to develop an allergy skin test to help predict allergic responses to medications commonly given to patients during surgery.

Full description

This study will be a prospective study to accurately determine the negative predictive value of skin testing with NMBAs.

It is hypothesized that the concentrations that should be used for NMBAs are actually much lower than previously recommended and that the higher incidence of identifiable NMBA induced allergic reactions during anesthesia in the past may be due to irritation of the skin rather than a true allergic reaction (false positives).

Enrollment: 187 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All adults > or = to 18 y/o undergoing surgery

Exclusion criteria

• Minors under the age of 18 y/o, Adults unable to consent, or those Adults with previous allergic reaction history during previous surgeries.

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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187 participants in 1 patient group

Study Group

Experimental group

Description:

Study team is developing a new diagnostic skin testing procedure for patients who receive NMBAs during surgery in order to determine Negative Predictive Values and Non-Irritant Concentrations.

Treatment:

Diagnostic Test: Skin Testing