Neuromuscular Complications of MEK Inhibitors: a French Case Series and a Systematic Review of the Literature

Central Hospital, Nancy, France

Status: Not yet enrolling

Conditions: Myositis; Parsonage Turner Syndrome; Myasthaenia Gravis; Neuropathy; Guillain Barré Syndrome

Treatments: Other: No Interventions

Study type: Observational

Funder types: Other

Identifiers

NCT06740656

2024PI240

Details and patient eligibility

About

MEK inhibitors (trametinib, cobimetinib, selumetinib or binimetinib) have been used since 2016 to treat metastatic melanoma, by targeting the MAPK pathway Neuromuscular complications (neuropathy, myasthenia or myositis) have been reported in patients treated with MEK inhibitors.

With the growing use of these new oncology therapies, neurologists, oncologists and other clinicians are likely to be increasingly confronted with MEK inhibitor-induced neuropathy, myasthenia or myositis.

Yet, so far, these complications have only been documented in a few single case reports.

Our aim was to characterize the neuromuscular complications associated with MEK inhibitors used either alone or in combination.

Enrollment: 5 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with neuromuscular complications of MEK inhibitors used alone or in combination
• Age > 18 years

Exclusion criteria

• Refusal of data collection