Neuromuscular Electrical Stimulation (NMES) and Muscle Protein Accretion (ES-PRO)

Maastricht University Medical Centre (MUMC)

Status: Completed

Conditions: Sarcopenia

Treatments: Device: Enraf Nonius Tensmed S84 for Neuromuscular electrical stimulation (NMES); Device: No Enraf Nonius Tensmed S84 for Neuromuscular electrical stimulation (NMES) NMES

Study type: Interventional

Funder types: Other

Identifiers

NCT01615276

MEC 12-3-020

Details and patient eligibility

About

In the present study, the effect of a bolus of intrinsically labeled milk directly after one-legged NMES will be studied.

Enrollment: 10 patients

Sex: Male

Ages: 65 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male
• Age 65 - 85 years
• 18.5 < BMI < 30 kg∙m2

Exclusion criteria

• Type II diabetes
• All co morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthrosis, arthritis, spasticity/rigidity, all neurological disorders, paralysis, hip/knee surgery).
• Use of anticoagulants, blood diseases, allergy for lidocaine
• Use of NSAIDs and acetylsalicylic acid
• Patients suffering from PKU (Phenylketonuria)
• Presence of implantable cardioverter defibrillator and/or pacemaker
• Performed regular resistance type exercise in the past 6 months

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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10 participants in 2 patient groups, including a placebo group

Protein ingestion

Placebo Comparator group

Description:

Protein ingestion directly after the contralateral leg received NMES

Treatment:

Device: No Enraf Nonius Tensmed S84 for Neuromuscular electrical stimulation (NMES) NMES

Protein ingestion after NMES

Experimental group

Description:

Ingestion of intrinsically labeled protein, directly after one hour of Neuromuscular electrical stimulation (NMES)

Treatment:

Device: Enraf Nonius Tensmed S84 for Neuromuscular electrical stimulation (NMES)