Neuromuscular Ultrasonography Utility for Detection of Peripheral Neuropathy in Systemic Lupus Erythematosus

Assiut University

Status: Completed

Conditions: Peripheral Neuropathy; System; Lupus Erythematosus

Treatments: Diagnostic Test: neuromuscular ultrasound

Study type: Observational

Funder types: Other

Identifiers

NCT04527172

17200346

Details and patient eligibility

About

This study aims to evaluate the rule of NMUS in detection of peripheral neuropathy in SLE patient and to correlate it to traditional neurophysiological studies, clinical signs and activity of SLE.

Full description

The frequency of SLE peripheral neuropathy documented by electrophysiology has been estimated to be approximately 30%.

The term peripheral neuropathies include symmetric polyneuropathy, single and multiple mononeuropathy, and radiculopathy.

There has been increasing interest in using ultrasonography (US) to aid peripheral neuropathy diagnosis and studies have shown good correlation with other imaging modalities. US is a non-invasive and inexpensive imaging device that has become widely available as a diagnostic tool at many fields.

so systemic lupus patients were enrolled in the study , performed nerve conduction study and neuromuscular ultrasound for bil. median, ulnar, peroneal, tibial and sural nerves , on statistics the cross sections were compared in neurophusiologically affected and non affected nerves, also the sensitivity and specifity of NMUS in comparison to the traditional NCS was calculated

Enrollment: 55 patients

Sex: All

Ages: 17+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. All adult SLE patients who was admitted to Rheumatology & Rehabilitation department of Assuit university hospital during time frame of study.
2. apparently healthy subjects with normal electrophysiological study
3. verbal consent, free and informed

Exclusion criteria

• • Other causes of peripheral neuropathy:

  1. Traumatic
  2. Purely degenerative
  3. Diabetic
  4. Toxic
  5. Infections
  6. Drug induced

Trial design

55 participants in 2 patient groups

systemic lupus patients

Description:

Nerve conduction study and neuromuscular ultrasound for median , ulnar, tibial, peroneal and sural nerves

Treatment:

Diagnostic Test: neuromuscular ultrasound

Healthy subjects

Description:

Nerve conduction study and neuromuscular ultrasound for median , ulnar, tibial, peroneal and sural nerves

Treatment:

Diagnostic Test: neuromuscular ultrasound