Neuromusuclar Adaptations in the Rheumatoid Arthritis Disease

Federal University of Rio Grande do Sul

Status: Completed

Conditions: Muscular Weakness; Arthritis, Rheumatoid

Treatments: Diagnostic Test: Neuromuscular and functional capacity tests

Study type: Observational

Funder types: Other

Identifiers

NCT03543488

09634

Details and patient eligibility

About

Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes joint inflammation and progressive joint destruction. Rheumatoid cachexia is one of the structural manifestations of RA, and consists of a reduction in muscle mass, due to an increased muscle protein catabolism induced by inflammatory cytokines. This muscle mass loss generates an impairment in physical function and functional capacity in RA patients. The aim of study was to verify neuromuscular and functional responses in middle-aged women with RA compared to paired healthy women.

Enrollment: 70 patients

Sex: Female

Ages: 25 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• RA patients with a class I and II RA diagnosis according to the American Rheumatism Association's 1987 revised criteria, were recruited from a university hospital's rheumatology clinic.

Exclusion criteria

• presence of any cardiovascular, neuromuscular and metabolic diseases or severe limitations in mobility

Trial design

70 participants in 2 patient groups

Rheumatoid Arthritis Patients

Description:

Forty women (range 25-75 years), with a class I and II RA diagnosis according to the American Rheumatism Association's 1987 revised criteria, were recruited from a university hospital's rheumatology clinic. Exclusion criteria included the presence of any cardiovascular, neuromuscular and metabolic diseases or severe limitations in mobility. Five patients were excluded for not attending the inclusion criteria, leading to a final number of 35 RA patients.

Treatment:

Diagnostic Test: Neuromuscular and functional capacity tests

Healthy Women

Description:

Thirty-five healthy women, age- and body size-matched to the RA patients, were recruited as controls (CG).

Treatment:

Diagnostic Test: Neuromuscular and functional capacity tests