Neuronal Effects of Exercise in Schizophrenia

University of Colorado Denver (CU Denver)

Status: Enrolling

Conditions: Schizophrenia

Treatments: Behavioral: Diet; Behavioral: Exercise

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT02455193

14-1282

R01MH102224 (U.S. NIH Grant/Contract)

UL1TR001082 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

This study plans to learn more about how common drugs prescribed to individuals with schizophrenia contribute to weight gain, as well as how exercise and diet impact appetite and the brain's response to food. In this study, the investigators will be evaluating how participants' brains respond to food images as well as asking questions about their food preferences and intake and clinical symptoms. The investigators may also ask participants to complete an exercise or diet intervention to see how this changes brain responses or food preferences.

Enrollment: 140 estimated patients

Sex: All

Ages: 21 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of schizophrenia or schizoaffective disorder
• Between 21 and 70 years of age
• Currently prescribed either olanzapine, risperidone, clozapine, or haloperidol, OR not currently being treated with any neuroleptic medications
• Weight stable within 5 percent for the last 6 months

Exclusion criteria

• Pregnancy
• Substance abuse
• Significant endocrine/metabolic disease (e.g., uncontrolled hypertension, severe hypertriglyceridemia)
• MRI-specific exclusion criteria (e.g., claustrophobia, metal in the body)

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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140 participants in 2 patient groups

Exercise intervention

Experimental group

Description:

10 weeks of a moderate exercise intervention

Treatment:

Behavioral: Exercise

Diet intervention

Active Comparator group

Description:

10 weeks of a diet intervention

Treatment:

Behavioral: Diet