Neuronal Excitability of HCN1 Channel Mutations in Dravet Syndrome (EXCIDRAH)

Fondation Ophtalmologique Adolphe de Rothschild

Status: Completed

Conditions: Dravet Syndrome

Treatments: Device: measure of neuronal excitability

Study type: Observational

Funder types: NETWORK

Identifiers

NCT02896608

AGN_2015_11

Details and patient eligibility

About

This study addresses the changes in the axonal excitability parameters. It will compare these changes in patients with early infantile epileptic encephalopathy with HCN1 channel mutation and in control patients, with and without epilepsy.

Enrollment: 92 patients

Sex: All

Ages: 15+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• early infantile epileptic encephalopathy with HCN1 channel mutation
• control patients with no neurologic pathology (age, gender and body temperature matched)
• epileptic patients (age, gender and body temperature matched)

Exclusion criteria

• pregnant or breast feeding patient

Trial design

92 participants in 3 patient groups

Dravet syndrome - HCN1 channel mutation

Description:

early infantile epileptic encephalopathy with HCN1 channel mutation

Treatment:

Device: measure of neuronal excitability

control with epilepsy

Treatment:

Device: measure of neuronal excitability

control without epilepsy

Treatment:

Device: measure of neuronal excitability