Neuropathic Pain in Psoriatic Arthritis

Bezmialem Vakif University

Status: Completed

Conditions: Psoriatic Arthritis

Treatments: Other: Disease activity in psoriatic arthritis (DAPSA); Other: painDETECT questionnaire; Other: Short form-36; Other: Spondyloarthritis Research Consortium of Canada Enthesitis Index (SPARCC); Other: Douleur Neuropathique 4 questionnaire (DN4); Other: Numeric Rating Scale

Study type: Observational

Funder types: Other

Identifiers

NCT05223049

2020-06/95

Details and patient eligibility

About

Pathogenesis of inflammatory diseases is suitable for eliciting neuropathic pain. The aim of this study is to evaluate the frequency of NP among PsA patients and relationship between disease activity, quality of life, functionality, and other numerous factors.

Full description

Neuropathic pain (NP) is the pain arising from a primary lesion or a dysfunction of nervous system. NP can affect central or peripheral nervous system and can be caused by numerous factors such as inflammation or neuroplastic changes. Inflammation can sensitize nociceptors in sensory nerves by promoting prostaglandin E2 and I2 secretion thus, cause neuropathic pain. Besides, a mixed pain pattern with neuropathic components is thought to be developed in chronic pain conditions. In this point of view, pathogenesis of inflammatory diseases is suitable for eliciting NP. In arthritic joints, even non-arthritic tissues are affected by the disease and a condition called peripheral sensitization develops. Previous studies about NP and inflammatory diseases link have focused on rheumatoid arthritis and number of studies about NP and psoriatic arthritis (PsA) is limited. In this manner the aim of this study is to evaluate the frequency of NP among PsA patients and relationship between disease activity, quality of life, functionality, and other numerous factors.

Enrollment: 45 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• being aged≥18
• being diagnosed PSA according to CASPAR criteria

Exclusion criteria

• additional conditions that could cause neuropathic pain (e.g. radiculopathy, polyneuropathy, depression, fibromyalgia)
• history of fracture or surgery
• endocrinopathies that could cause neuropathic pain (e.g. DM)
• malignancy

Trial design

45 participants in 2 patient groups

Psoriatic Arthritis patients with neuropathic pain

Description:

Patients diagnosed with Psa according to The Classification Criteria for Psoriatic Arthritis (CASPAR) psoriatic arthritis criteria. Who has a DN4 score of ≥4 or PainDETECT score of ≥13.

Treatment:

Other: Disease activity in psoriatic arthritis (DAPSA)

Other: painDETECT questionnaire

Other: Short form-36

Other: Numeric Rating Scale

Other: Spondyloarthritis Research Consortium of Canada Enthesitis Index (SPARCC)

Other: Douleur Neuropathique 4 questionnaire (DN4)

Psoriatic Arthritis patients with nonneuropathic pain

Description:

Patients diagnosed with Psa according to The Classification Criteria for Psoriatic Arthritis (CASPAR) psoriatic arthritis criteria. Who has a DN4 score of ≤4 or PainDETECT score of ≤13.

Treatment:

Other: Disease activity in psoriatic arthritis (DAPSA)

Other: painDETECT questionnaire

Other: Short form-36

Other: Numeric Rating Scale

Other: Spondyloarthritis Research Consortium of Canada Enthesitis Index (SPARCC)

Other: Douleur Neuropathique 4 questionnaire (DN4)