Neurophysiological Changes After Perturbation-based Training in Older Adults

The Hong Kong Polytechnic University

Status: Enrolling

Conditions: Postural Stability; Community Dwelling Older Adults; Falling; Brain Structure; Brain Connectivity

Treatments: Behavioral: Perturbation-based balance training (PBT); Behavioral: Walking exercise (control)

Study type: Interventional

Funder types: Other

Identifiers

NCT06573658

HSEARS20230928002

Details and patient eligibility

About

This is an assessor-blinded neurophysiological study. Participants will be randomly assigned to a perturbation-based training (PBT) or a walking (control) group. Changes in postural stability and neurophysiology in the brain following PBT compared to walking exercise without perturbation will be investigated.

Full description

A total of 88 participants will be randomly assigned to two groups receiving perturbation-based training (PBT) or walking exercise without perturbation (control). Written informed consent will be obtained from participants prior to the baseline assessment. The study will be reported and conducted in line with the CONSORT statement. Participants will be recruited via convenience sampling in the local community. Both groups will receive two sessions of treadmill walking at their comfortable speed. Perturbations will be induced during treadmill walking only for the PBT group. As informed from previous literature, two sessions of PBT could have improved postural stability for up to 1.5 years. Between-group differences in behavioural and MRI findings will be examined before and after training to identify training-induced changes in postural stability, brain structures, and functional connectivities. Retention of the changes in the postural stability will be assessed four months after the training period. Incidents of falls will be followed up for 12 months after training.

Enrollment: 88 estimated patients

Sex: All

Ages: 60+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Aged ≥ 60 years old
• Community-dwelling
• Right-handed
• Able to communicate effectively in Cantonese or Mandarin
• Able to walk independently on level ground for ≥ 30 minutes
• Abbreviated Mental Test (Hong Kong version) score ≥ 6

Exclusion criteria

• Metal implants (e.g. pacemaker, artificial cochlea)
• Uncorrected vision or hearing impairment
• Osteoporosis
• Hip or knee replacement within the last year
• Musculoskeletal, cardiovascular, mental, or neurological disorders (such as Parkinson's disease) which can affect MRI examination, balance control, or exercise participation.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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88 participants in 2 patient groups, including a placebo group

Perturbation-based balance training group

Experimental group

Description:

This group will receive two sessions of treadmill walking at their comfortable speed involving perturbations

Treatment:

Behavioral: Perturbation-based balance training (PBT)

Control

Placebo Comparator group

Description:

This group will receive two sessions of treadmill walking at their comfortable speed involving no perturbations

Treatment:

Behavioral: Walking exercise (control)