Neurophysiological Correlates of Cognitive Tasks in Healthy Volunteers -WP3 P003 (PharmacogWP3)

University Hospital, Lille

Status

Unknown

Conditions

Alzheimer Disease

ELECTROENCEPHALOGRAPHIC VARIANT PATTERN 1 (Disorder)

Treatments

Other: Rapid Visual Information Processing (RVIP) test

Study type

Interventional

Funder types

Other

Identifiers

NCT02899403

2015-A00046-43 (Other Identifier)

2013_45

Details and patient eligibility

About

In the perspective to better evaluate the efficacy of new treatment strategies for Alzheimer disease (AD), it appears important to develop experimental paradigms to precisely measure cognitive endpoints/biomarkers that may be used in healthy volunteers as tools to validate drug efficacy profile.

The use of Electroencephalography (EEG) may be, therefore, a good candidate. The purpose of the present study is to use EEG to more precisely explore cognitive processes in healthy subjects, with a particular interest in episodic and working memory functions that are usually altered in both AD and Mild Cognitive Impairment (MCI) as well as to better understand underlying neural mechanisms involved in these processes.

Enrollment

20 estimated patients

Sex

Male

Ages

18 to 30 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Right-handed
In good health on the basis of the medical interview (medical history, symptoms), the physical examination and vital signs
Non smoker and with no history of drug or alcohol abuse
Without chronic treatment
With normal hearing and normal vision including color (with correction)
French speaker and able to understand the test instructions
Has provided written informed consent
Able to read and understand the Information Form and comply with the protocol instructions and restrictions

Exclusion criteria

Cognitive impairment (MoCA < 26)
Cognitive complaint (MacNair Scale > 15)
History of brain disease (severe brain trauma, stroke, cerebral tumor...) or current cerebral disease
Major medical or surgical history
Current chronic disease
Vascular or metabolic risk factor
History or current mental disease or addiction (MINI)
Family history of young onset dementia
Family history of chronic or severe neurological or mental disease (first degree relatives)
In the opinion of the investigator, is unlikely to comply with the study protocol or is unsuitable for any other reason
Participates to another clinical trial or is still being within a washout period of a previous clinical trial
Already exposed to cognitive tests used in this study.