Neurophysiological Evaluation of Schizophrenia Patients After Cognitive and Physical Intervention

Aristotle University Of Thessaloniki

Status: Completed

Conditions: Schizophrenia

Treatments: Other: Cognitive Training; Other: Physical Training

Study type: Interventional

Funder types: Other

Identifiers

NCT03899662

SCH15973

Details and patient eligibility

About

Neurophysilogical, neuropsychological evaluation and cognitive and physical training

Full description

24 sessions (8 weeks, 3 times per week) of cognitive and physical training via computer. Each session consisted of 45 minutes of cognitive traing (BrainHQ platform https://www.brainhq.com/) and 45 minutes of physical training (FitForAll platform https://www.fitforall.gr/play/app/). Cognitive training included memory, attention, velocity, intelligence etc. Physical training included aerobic, strength flexibility and other excercises. All evaluations were performed 1-14 before the initiation of the interventions and 1-14 after their completion. Neurophysiological evaluation consisted of EEG with the use of 128 electrode-machine and the protocol included 5 minuted of eyes closed and 5 minutes of eyes open. Neuropsychological evaluation included Trail Making Test (A & B), Verbal Fluency, Stroop test, Wechsler Memory - Cubes (visuospatial), MoCA, FAB (Screening for frontal damage) and Eyes Test (Theory of Mind). Also, the physical condition evaluation included 6-Minute Walking Distance (6MWD), ΒΜΙ, HandGrip Strength Test, Short Physical Performance Battery Protocol.

Enrollment: 4 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• a diagnosis of schizophrenia disorder according to ICD10 criteria
• clinically stable patients (no recent change in psychotropic medication except benzodiazepines)
• sufficient acculturation and fluency in Greek language
• assent of the attending physician for participation in the study

Exclusion criteria

• co-morbidity with neurological disorders (e.g.epilepsy) or head injury
• a pathological or other somatic disorder that contraindicate physical exercise
• alcoholism and substance abuse within the previous 3 months (except caffeine and tobacco)
• abstainance from intervention for more than 12 days
• cognitive decline
• treated with Benzodiazepine

Trial design

Primary purpose: Health Services Research

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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4 participants in 1 patient group

Cognitive and Physical Training

Experimental group

Description:

24 sessions (8 weeks, 3 times per week) of computer based 45 minute cognitive and 45 minute physical training.

Treatment:

Other: Cognitive Training

Other: Physical Training