Neurophysiological Study of tDCS Effects in Healthy Volunteers (tDCSHV)

University of Liege

Status and phase: Completed; Phase 1

Conditions: Healthy Volunteers

Treatments: Device: Cefaly tDCS

Study type: Interventional

Funder types: Other

Identifiers

NCT02125422

CB-1200

Details and patient eligibility

About

Transcranial direct current stimulation is a tool to modulate cortical excitability.

Full description

Anodal transcranial direct currenti stimulation over visual cortex is able to decrease the thermo-nociceptive sensibility and thermonociceptive potentials, whilst cathodal transcranial direct current stimulation has the opposite effect, it decreases VEP amplitude and habituation. This neuromodulation technique is probably a tool in the prevention in episodic and chronic migraine.

The aim of the study is to study short and long term effect of tDCS over pain treshold, contact heat evoked potentials, blink reflex and visual evoked potentials in healthy volunteers.

Enrollment: 18 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy volunteers

Exclusion criteria

• age below 18 or above 65 years
• personal history of recurrent headache or other neurological diseases especially seizures,
• familial history of recurrent headache
• child migraine equivalents (motion sickness, cyclic vomiting or recurrent abdominal pain, somnambulism etc.. . .)
• chronic pain syndromes
• analgesics intake at the time of recording
• contra-indications to tDCS neurostimulation (metal prosthetics in the head or internal stimulation like a pacemaker).

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

18 participants in 1 patient group

Cefaly tDCS

Experimental group

Description:

Cathodal Cefaly tDCS is delivered over the visual cortex at 2 mA of intensity, for 20 minutes, for 5 consecutive days in 9 HV. The anode is placed over the left DLPFC. 2 mA anodal tDCS is delivered over the visual cortex, for 20 minutes, for 5 consecutive days in 9 HV

Treatment:

Device: Cefaly tDCS