Neurophysiology of the Basal Ganglia, Thalamus, and Cerebellum in Patients With Movement Disorders

University of Pennsylvania

Status: Not yet enrolling

Conditions: Movement Disorders

Treatments: Other: Prescribed Medications; Other: Deep brain stimulation adjustment

Study type: Interventional

Funder types: Other

Identifiers

NCT06848530

857558

Details and patient eligibility

About

The research study is being conducted to better understand parts of the human brain called the cortex, basal ganglia, thalamus, and cerebellum in patients with movement disorders (such as Parkinson's disease, essential tremor, dystonia, or ataxia). These brain structures are involved in movement disorders. This study attempts to better understand the brain electrical activity associated with these disorders, both in patients with and without deep brain stimulation (DBS). Recordings are made from the scalp with a noninvasive electrode and/or through the DBS stimulator if the participant has a stimulator model that is able to sense brain activity. These recordings are analyzed along with measures of movement disorder symptoms to identify brain signal signatures of symptoms.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients 18 years of age and above
• Any patient who has been diagnosed by a movement disorders neurologist with one of the following movement disorders:
• Parkinson's disease
• Dystonia
• Tremor, including essential tremor
• Cerebellar ataxia
• Other hyperkinetic movement disorders, such as chorea and tics

Exclusion criteria

- Patients with dementia

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

100 participants in 2 patient groups

Participants without Deep Brain Stimulators

Experimental group

Description:

Multimodal neurophysiology (for example, electroencephalography and electromyography) will be measured during the following: Movement disorder medication administration -The patient's movement disorders medications, prescribed by their treating physicians outside of this study, may be administered during an experimental session.

Treatment:

Other: Prescribed Medications

Participants with Deep Brain Stimulators

Experimental group

Description:

Multimodal neurophysiology (for example, electroencephalography and electromyography) will be measured during the following: Movement disorder medication administration -The patient's movement disorders medications, prescribed by their treating physicians outside of this study, may be administered during an experimental session. Deep brain stimulator (DBS) adjustment - Participants who have had deep brain stimulation implantation as part of their standard-of-care clinical treatment may participate in this study. The patient's stimulator may be adjusted within normal clinical limits during an experimental session.

Treatment:

Other: Deep brain stimulation adjustment

Other: Prescribed Medications