Neuroprotection of Pioglitazone in Acute Ischemic Stroke

Taipei Medical University

Status and phase

Terminated

Phase 2

Conditions

Stroke

Treatments

Drug: Placebo

Drug: Pioglitazone

Study type

Interventional

Funder types

Other

Identifiers

NCT02195791

MOHW103-TDU-B-212-113001 S

Details and patient eligibility

About

Pioglitzone, an oral anti-diabetic drug which can reduce insulin resistance and decrease inflammation. It has been proven to be an effective neuroprotective agent in animal model of ischemic stroke. In this study, the investigators will conduct a phase II clinical trial (double-blind, randomized placebo controlled study) to survey the neuroprotection effect of pioglitazone in stroke patients with hyperglycemia. A total of 152 acute ischemic stroke patients with hyperglycemic will receive insulin or sulfonyurea for blood sugar control, and will be randomly randomized into intervention (Pioglitazone 30mg once a day p.o,) and control group (placebo). The investigators expect to prove the neuroprotective efficacy of Pioglitazone in acute stroke with hyperglycemia and identify the biomarkers associated with good neurological outcome in patients with Pioglitazone treatment from the investigators clinical trial.

Enrollment

4 patients

Sex

All

Ages

20+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Acute ischemic stroke onset within 48 hours
Age≧20 years
Stroke severity with at least one point for limb weakness in National Institutes of Health Stroke Scale (NIHSS).
The patients with no known history of diabetes with admission serum glucose ≧130 mg/dl.

Exclusion criteria

The patients who have history of urinary bladder cancer or hematuira.
The patients who have history of congestive heart failure or myocardial infarction.
The patients who have known history of using pioglitazone before the onset of stroke.
The patients who have mRS≧3 before stroke onset.