Neuropsychiatric and Cardiovascular Side Effects in Ketamine Analgesic Infusions

U

Universidad de Antioquia

Status

Completed

Conditions

Ketamine Adverse Reaction
Pain, Postoperative

Treatments

Drug: Ketamine

Study type

Interventional

Funder types

Other

Identifiers

NCT03525912
UdeA1002

Details and patient eligibility

About

Evaluation of neuropsychiatric and cardiovascular side effects of low dose ketamine analgesic infusion for postoperative pain

Full description

Postoperative pain is a world wide problem related with surgery. Multimodal analgesia may include ketamine, aimed to decrease opioid adverse effects in postoperative analgesia for major surgery, and risk of chronic postsurgical pain. Ketamine has shown efficacy as adjuvant in multimodal analgesia, however, neuropsychiatric and cardiovascular effects of ketamine at low doses in continue postoperative infusion are less known. This type of adverse effects may compromise appropriated recovery. Objective to determine frequency of delirium, agitation, sedation, hallucinations, bad dreams and cardiovascular changes associated with ketamine analgesic infusion treatment for postoperative pain.

Enrollment

101 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • patient scheduled for abdominal, thoracic or orthopedic surgery

Exclusion criteria

cognitive disfunction psychiatric illness cardiovascular disease

Trial design

Primary purpose

Treatment

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

101 participants in 1 patient group

Ketamine infusion
Experimental group
Description:
postoperative pain in adult population after abdominal, thoracic and orthopedic surgery that received adjuvant analgesia with ketamine 0.1mg/kg/h during 24 to 48 hours in postoperative period.
Treatment:
Drug: Ketamine

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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