Neuropsychiatric and Cardiovascular Side Effects in Ketamine Analgesic Infusions

Universidad de Antioquia

Status: Completed

Conditions: Ketamine Adverse Reaction; Pain, Postoperative

Treatments: Drug: Ketamine

Study type: Interventional

Funder types: Other

Identifiers

NCT03525912

UdeA1002

Details and patient eligibility

About

Evaluation of neuropsychiatric and cardiovascular side effects of low dose ketamine analgesic infusion for postoperative pain

Full description

Postoperative pain is a world wide problem related with surgery. Multimodal analgesia may include ketamine, aimed to decrease opioid adverse effects in postoperative analgesia for major surgery, and risk of chronic postsurgical pain. Ketamine has shown efficacy as adjuvant in multimodal analgesia, however, neuropsychiatric and cardiovascular effects of ketamine at low doses in continue postoperative infusion are less known. This type of adverse effects may compromise appropriated recovery.

Objective

to determine frequency of delirium, agitation, sedation, hallucinations, bad dreams and cardiovascular changes associated with ketamine analgesic infusion treatment for postoperative pain.

Enrollment: 101 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient scheduled for abdominal, thoracic or orthopedic surgery

Exclusion criteria

cognitive disfunction psychiatric illness cardiovascular disease

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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101 participants in 1 patient group

Ketamine infusion

Experimental group

Description:

postoperative pain in adult population after abdominal, thoracic and orthopedic surgery that received adjuvant analgesia with ketamine 0.1mg/kg/h during 24 to 48 hours in postoperative period.

Treatment:

Drug: Ketamine