Neuropsycholgy and Neuroimaging in Transient Global Amnesia (2NIA)

Caen University Hospital

Status: Terminated

Conditions: Transient Global Amnesia (TGA)

Treatments: Behavioral: Neuropsychological tests; Device: Cerebral imaging (MRI, PET-FDG)

Study type: Interventional

Funder types: Other

Identifiers

NCT02562560

2007-A00910-53

Details and patient eligibility

About

The purpose of this study is to establish a diagnosis in transient global amnesia (TGA) in assessing three episodic memory's abilities (mental simulation throught the future, and the past, the learning of personnal actions i-e the enactment effect). Secondary goal is to describe the neuronal substrates associated to the alteration of theses abilites in TGA.

Enrollment: 60 patients

Sex: All

Ages: 30 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All the participants

  • Minimum of 7 years of education
  • French native speaker

• Healthy subjects : Non pathological Dementia rating scale score

• Patients : Clinical diagnosis of TGA according to Hodges and Warlow's criterion

Exclusion criteria

• Chronic neurological disease
• Encephalitis
• Endocrinal disease
• Hepatic disease
• Case history of head injury with loss of consciousness of more than one hour
• Case history of stroke
• Case history of cancer during the five last years except squamous cell carcinomas
• Alcoholism or drug addiction
• Major psychiatric disorders according the Diagnostic and Statistical Manual of -Mental Disorders

Trial design

60 participants in 2 patient groups

TGA

Experimental group

Treatment:

Device: Cerebral imaging (MRI, PET-FDG)

Behavioral: Neuropsychological tests

Controls

Experimental group

Treatment:

Device: Cerebral imaging (MRI, PET-FDG)

Behavioral: Neuropsychological tests