Neuropsychological Evaluation for Early Diagnosis of PSP

Ospedale Generale Di Zona Moriggia-Pelascini

Status: Completed

Conditions: Cognitive Impairment; Progressive Supranuclear Palsy

Treatments: Behavioral: Cognitive evaluation

Study type: Observational

Funder types: Other

Identifiers

NCT03478124

NPsy-PSP

Details and patient eligibility

About

The aim of this study is to better understand the nature of the cognitive decline in Progressive Supranuclear Palsy, the time of its development and the relation with the other cardinal features of the disease.

Full description

Progressive Supranuclear Palsy (PSP) is a neurodegenerative disease characterized by vertical supranuclear gaze palsy, early balance dysfunction and falls. Tau-protein aggregation, mainly in the brainstem, is the disease hallmark. Because of the similarities with Parkinson's disease (PD), the diagnosis is made approximately 4 years after the symptoms onset. Cognitive deficits are a leading feature of PSP and they actually represent one of the four functional core domains in the revised diagnostic criteria. The aim of this study is to better understand the nature of this cognitive decline, the time of its development and the relation with the other cardinal features of the disease.

Enrollment: 112 patients

Sex

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients fulfilling the criteria for idiopathic PD
• Patients fulfilling the criteria for PSP

Exclusion criteria

• Any other neurodegenerative disorders or medical conditions different from PD / PSP

Trial design

112 participants in 2 patient groups

PSP patients

Description:

Patients suffering from Progressive Supranuclear Palsy (PSP)

Treatment:

Behavioral: Cognitive evaluation

PD Patients

Description:

Patients suffering from Parkinson's disease (PD)

Treatment:

Behavioral: Cognitive evaluation