Neuropsychological Indicators of SCD Progression (SCD-CI)

Centre Hospitalier Universitaire, Amiens

Status: Completed

Conditions: Biomarkers; Neurodegenerative Diseases; Cognitive Decline; Cognitive Assessment; Subjective Cognitive Decline; Neurocognitive Disorders

Study type: Observational

Funder types: Other

Identifiers

NCT04880252

PI2019_843_0039

Details and patient eligibility

About

Some patients with subjective cognitive decline (SCD) progress to neurocognitive disorders (NCD), whereas others remain stable; however, the neuropsychological determinants of this progression have not been identified. The investigators objective was to examine baseline neuropsychological indicators that could discriminate between people in whom the SCD progressed to a mild or major NCD and people in whom the SCD remained stable.

The investigators retrospectively included patients consulting for SCD at a university medical center's memory center (Amiens, France) and who had undergone three or more neuropsychological assessments at least 6 months apart. The relationship between domain-specific scores and the global cognitive score (GCS, as a function of final status (stable SCD vs. progression toward a mild or major NCD)) was examined using a generalized linear mixed model.

Enrollment: 80 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients who had been referred to the memory center at Amiens University Medical Center (Amiens, France).
• patients who had undergone three neuropsychological assessments at least 6 months apart, from 2005
• patients who met the criteria for SCD.

Exclusion criteria

• patients who didn't meet the criteria for SCD