Neuropsychological Profiles and Musical Engagement in Parkinson's and Alzheimer's Disease (MUSENGAGE)

University Hospital Center (CHU)

Status: Enrolling

Conditions: Non Pharmacological Intervention; Parkinsons Disease with Dementia; Alzheimer Disease, Early Onset

Treatments: Behavioral: questionnaire; Behavioral: neuropsychologist interview

Study type: Interventional

Funder types: Other

Identifiers

NCT06688968

RECHMPL23_0427

Details and patient eligibility

About

The goal of this Multicenter observational pilot study is to Compare the specifics of musical engagement (behaviors related to music in everyday life) in subjects aged over 60 with Alzheimer s disease, Parkinson s disease and control subjects.

The main questions it aims to answer are:

1. The description of different profiles of musical engagement in early-stage AD, in PD and in healthy elderly subjects.
2. The extent of executive, mnestic and hedonic dysfunctions will impact differently on emotional engagement, autobiographical evocation and sensitivity to musical reward, and will therefore enable distinct profiles to be drawn up.

Participants will have an intervention consisting of an interview with a neuropsychologist lasting approximately 2 hours, including :

• A semi-structured interview to check the participants eligibility and gather demographic data.
• Neuropsychological tests and questionnaires will then be administered.
• A relative of the study participant will help complete questionnaires.

Full description

Music therapy appears to be highly relevant as a Non-Medication Intervention in Alzheimer s (AD) and Parkinson s disease (PD). It is said to reduce depressive symptoms following music therapy sessions in dementia . With regard to Parkinson s disease, music therapy brings benefits in terms of motor skills, communication, breathing and emotional aspects. Reviews point to the need to differentiate beneficial effects according to different pathologies.

To date, no study has investigated the evolution of sensitivity to musical reward in AD. Furthermore, no study has discriminated the evolution of musical engagement in several neurodegenerative pathologies.

Enrollment: 120 estimated patients

Sex: All

Ages: 60+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

General inclusion criteria:

• 60 years and older
• French-speaking and volunteering for the study
• Living at home with a relative

Alzheimer's disease inclusion criteria:

• Biological diagnosis of probable Alzheimer's disease according to NINCDS-ADRDA criteria (McKhann et al., 1984)
• MMSE greater than or equal to 20

Inclusion criteria Parkinson's disease :

• Diagnosis of Idiopathic Parkinson's disease
• MMSE greater than or equal to 20

Exclusion criteria

• No known neurological pathologies (epilepsy and other non-degenerative CNS diseases) or psychiatric disorders (chronic psychosis and psychotic episodes)
• Autistic disorders
• History of stroke or head trauma
• Unstable medical condition (cancer)
• Subject unable to read and/or write
• Hearing impairment without hearing aids
• Refusal of consent after information
• Persons unable to give consent, research carried out in emergency situations, etc.)
• Non-affiliation with a social security scheme
• Person deprived of liberty (by judicial or administrative decision, or forced hospitalization)
• Person under legal protection (guardianship, curatorship, legal protection)
• Person participating in another research project with an exclusion period still in progress

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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120 participants in 3 patient groups

patient with early-onset Alzheimer's disease (AD)

Experimental group

Description:

patients followed up at the Centre Mémoire de Ressources et de Recherche (CMRR) of Montpellier, over 60 with Alzheimer's disease who have cognitive impairment based on an MMSE (Mini Mental State Examination) ≥ 20 and live at home with a relative

Treatment:

Behavioral: neuropsychologist interview

Behavioral: questionnaire

patients with parkinson's disease (PD)

Active Comparator group

Description:

patients followed up at the Center Expert Parkinson of Montpellier (CEPMo), over 60 with Parkinson's disease who have cognitive impairment based on an MMSE (Mini Mental State Examination) ≥ 20 and live at home with a relative

Treatment:

Behavioral: neuropsychologist interview

Behavioral: questionnaire

Healthy control

Active Comparator group

Description:

Subjects aged over 60, with no known neurodegenerative disease, living at home with a relative in the Hérault département.

Treatment:

Behavioral: neuropsychologist interview

Behavioral: questionnaire