Neuropsychological Profiles of Children With Duchenne Muscular Dystrophy and Its Effects on Motor Functions

Hacettepe University

Status: Active, not recruiting

Conditions: Duchenne Muscular Dystrophy

Treatments: Other: Strengths and Difficulties Questionnaire (Self-Reported); Other: Conners' Parent Rating Scale-48 (Parent Report); Other: Modified Mini Mental Test:; Other: The Central Nervous System Vital Signs; Other: Four Square Step Test; Other: Six Minutes Walk Test; Other: Child Behavior Checklist 6-18 ages (Parent Report); Other: Motor Function Measurement-32 Items; Other: Timed Performance Test; Other: Brooke Lower Extremity Functional Classification; Other: The Controlled Oral Word Association Test

Study type: Observational

Funder types: Other

Identifiers

NCT05661071

GO22/310

Details and patient eligibility

About

This study was planned to determine neuropsychological profiles of children with Duchenne Muscular Dystrophy and investigation of its effects on motor functions & compare to typically developed peers.

Full description

In this thesis, it is aimed to determine the neuropsychological profiles of children with Duchenne Muscular Dystrophy (DMD) and to investigate its effects on motor functions. The study will be carried out with children between the ages of 7 and 16 who have been diagnosed with DMD as a result of genetic testing and who applied to Hacettepe University, Faculty of Physical Therapy and Rehabilitation, Pediatric Neuromuscular Diseases Unit for physiotherapy and rehabilitation evaluation. In addition, considering the primary purpose of the study, typically developed boys between the ages of 7 and 16 with similar physical characteristics will be included in the study and compared with children with DMD. Typically developed boys included in the study will be evaluated only with neuropsychological tests. Evaluating cognitive function from neuropsychological tests; Modified Mini Mental Test, The Controlled Oral Word Association Test,computer-based The Central Nervous System Vital Signs will be applied. To evaluate neurodevelopmental status from neuropsychological tests; Conners' Parent Rating Scale, Child Behavior Checklist, Strengths and Difficulties Questionnaire (SDQ) will be applied. To evaluate the motor functions of individuals with DMD; Brooke Lower Extremity Functional Classification, Motor Function Measurement, Four Square Step Test, Six Minutes Walk Test, Timed Performance Tests (10 meters Walk/Run Test, Gower's (from a supine to a standing position), Right/Left Leg Standing, Ascent/Descent of 4 Steps) will be used. In the study, in which the effect of the mutation region of dystrophin protein isoforms causing DMD on the neuropsychological profile of children will be investigated by comparing them with typically developed boys and the effect of this on motor function will be examined, the statistical significance level will be considered as p<0.05

Enrollment: 74 patients

Sex: Male

Ages: 7 to 16 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Having been diagnosed with DMD by a pediatric neurologist,
• Being between the ages of 7-16,
• Not to have any diagnosed chronic disease,
• Not having lost yet the ability to write and draw as required by neuropsychological assessments,
• Cooperate with the physiotherapist and be able to comply with their instructions.

Exclusion criteria

• Inability to cooperate adequately with the physiotherapist who made the evaluations,
• Have had any injury and/or surgery to the lower/upper extremities in the last 6 months, which may prevent the performance of motor function tests.

Trial design

74 participants in 2 patient groups

Duchenne Muscular Dystrophy

Description:

Children with Duchenne Muscular Dystrophy (DMD) between the ages of 7 and 16 who have been diagnosed with DMD as a result of genetic testing

Treatment:

Other: Strengths and Difficulties Questionnaire (Self-Reported)

Other: Conners' Parent Rating Scale-48 (Parent Report)

Other: Modified Mini Mental Test:

Other: Timed Performance Test

Other: Six Minutes Walk Test

Other: Four Square Step Test

Other: The Central Nervous System Vital Signs

Other: Brooke Lower Extremity Functional Classification

Other: The Controlled Oral Word Association Test

Other: Child Behavior Checklist 6-18 ages (Parent Report)

Other: Motor Function Measurement-32 Items

Typically Developed Children

Description:

Typically Developed Children with similar physical characteristics between the ages of 7 and 16

Treatment:

Other: Strengths and Difficulties Questionnaire (Self-Reported)

Other: Conners' Parent Rating Scale-48 (Parent Report)

Other: Modified Mini Mental Test:

Other: The Central Nervous System Vital Signs

Other: The Controlled Oral Word Association Test

Other: Child Behavior Checklist 6-18 ages (Parent Report)