Neurosensory Abnormalities in SymptomAtic Ocular Surface Patients (NASA)
Status
Invitation-only
Conditions
Dry Eye
Neuropathic Pain
Treatments
Other: Contact Lens Dry Eye Questionnaire-8 (CLDEQ-8) Optional; only for Contact Lens Wearers
Other: Visual Analogue Questionnaire
Other: Hyperosmolar Response
Other: Ocular Pain Assessment Survey (OPAS)
Other: Proparacaine Challenge Test
Details and patient eligibility
About
This study is designed to measure how common nerve abnormalities are within a group of patients who feel discomfort within their eyes.
Enrollment
1,000 estimated patients
Sex
All
Ages
18+ years old
Volunteers
No Healthy Volunteers
Inclusion criteria
- Presents with ocular surface discomfort or for dry eye care
- Best corrected visual acuity of 20/40 or better in each eye
- Subject reported duration of symptoms of at least 3 months
- 100 subjects will be required to be habitual contact lens wearers as defined by use of contact lenses at least 5 hours per day at least 5 days per week for the last year.
Exclusion criteria
- Use of contact lenses on the day of the visit
- Pregnant or nursing
- Irregular corneas (e.g., ectatic disease, transplantation, or corneal dystrophies)
- Ocular surgery in the past 3 months
- Ocular infection in the past 3 months
- Active ocular allergies
Trial design
1,000 participants in 3 patient groups
Neuropathic Corneal Pain with Ocular Surface Discomfort
Description:
Participants diagnosed with neuropathic corneal pain with ocular surface discomfort
Treatment:
Other: Proparacaine Challenge Test
Other: Ocular Pain Assessment Survey (OPAS)
Other: Hyperosmolar Response
Other: Visual Analogue Questionnaire
Other: Contact Lens Dry Eye Questionnaire-8 (CLDEQ-8) Optional; only for Contact Lens Wearers
Neuropathic Corneal Pain with Dry Eye Disease
Description:
Participants diagnosed with dry eye disease and neuropathic corneal pain
Treatment:
Other: Proparacaine Challenge Test
Other: Ocular Pain Assessment Survey (OPAS)
Other: Hyperosmolar Response
Other: Visual Analogue Questionnaire
Other: Contact Lens Dry Eye Questionnaire-8 (CLDEQ-8) Optional; only for Contact Lens Wearers
NCP or Dry Eye in patients with ocular surface discomfort
Description:
Participants diagnosed with neuropathic corneal pain or with a neuropathic component of dry eye in patients with ocular surface discomfort
Treatment:
Other: Proparacaine Challenge Test
Other: Ocular Pain Assessment Survey (OPAS)
Other: Hyperosmolar Response
Other: Visual Analogue Questionnaire
Other: Contact Lens Dry Eye Questionnaire-8 (CLDEQ-8) Optional; only for Contact Lens Wearers
Trial contacts and locations
16
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Data sourced from clinicaltrials.gov
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