Neurotoxic Health Hazards of Long-Term Low-Level Exposure to Organophosphate (OP) Compounds in in Hula Valley

Shaare Zedek Medical Center

Status: Unknown

Conditions: Peripheral Neuropathy

Study type: Observational

Funder types: Other

Identifiers

NCT00671866

y.finkelstein.ctil.

Details and patient eligibility

About

During 1987-1991, WHO supported studies of exposures and short term neurobehavioral effects in a cohort (n=200) with occupational and community exposures to pesticide drift containing organophosphates from orchards and cotton fields in the Hula Valley. We aim (1) to re-examine neurobehavioral outcomes in members of the original cohort and (2) to examine cognitive effects in children with residential exposures. In adults, we will carry out assays of alkyl phosphates, PON1 (paraoxonase-1), NTE (Neuropathy Target Esterase), neurobehavioral tests of cognitive and performance skills, nerve conduction measurements and mood status. We will carry out Psycho-Didactic tests in children. The findings will advance knowledge on delayed term health effects of lengthy everyday exposure to OP pesticides and guide regulatory policy.

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Participants of the former study twenty years ago

Trial design

0 participants in 3 patient groups

1

Description:

Agricultural Workers

2

Description:

Non - Agricultural Workers

3

Description:

Kibbitz Residents working else where