Neurotoxicity of Anesthesia in Middle Aged Patients

Tanta University

Status: Unknown

Conditions: Anesthesia; Adverse Effect

Treatments: Drug: Anesthesia Agent

Study type: Observational

Funder types: Other

Identifiers

NCT04275531

neurotoxicity of anesthesia

Details and patient eligibility

About

for the last 20 years, the increasing reports from non-human studies have raised suspicion that general anesthetics may cause neurotoxic changes in the developing brain that lead to adverse neurodevelopmental outcomes later in life.there are several case reports of reversible smell and taste dysfunction following exposure to general anesthesia suggesting a possible relationship between anesthetic agents and olfactory dysfunction.

this study is to assess the possible neurotoxicity of sevoflurane,isoflurane,and propofol based anesthesia guided by olfactory changes

Full description

the primary inhibitory neurotransmitter GABA is found in neuronal synapses involving olfactory bulb. So, the involvement of common GABA pathway implies a possible interaction of general anesthetics with olfactory function.

olfactory identification is an associative memory which is found to be facilitated by action of melatonin. involvement of GABA receptor in the transfer of light information from suprachiasmatic nuclei to pineal gland suggests possible interaction of melatonin and anesthetic agents.

the aim of the study is to evaluate the possible neurotoxicity of sevoflurane,isoflurane,and propofol based anesthesia guided by olfactory changes

Enrollment: 600 estimated patients

Sex: All

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients aged 18-50 years
• both sex
• American society of Anesthesiologists' physical status I and II
• elective surgery of duration 90-120 minutes

Exclusion criteria

• patients's refusal
• recent airway infection
• allergic rhinitis
• nasal polyps
• history of alcoholism
• smoking
• pregnancy
• menstruating female
• mental retardation
• psychiatric illness
• neurosurgical or oto-rhino-laryngeal surgery
• history of olfactory deficits or cognitive impairment
• CNS disease e.g. epilepsy
• history of first degree relative with alzheimer's disease,dementia, or cognitive dysfunction
• those who are unable to answer the tests themselves

Trial design

600 participants in 4 patient groups

regional anesthesia

Description:

surgical procedures which will be performed under intrathecal anesthesia without sedation

Treatment:

Drug: Anesthesia Agent

sevoflurane

Description:

surgical procedures which will be performed under general anesthesia and sevoflurane will be used for maintenance of anesthesia

Treatment:

Drug: Anesthesia Agent

isoflurane

Description:

surgical procedures which will be performed under general anesthesia and isoflurane will be used for maintenance of anesthesia

Treatment:

Drug: Anesthesia Agent

propofol

Description:

surgical procedures which will be performed under general anesthesia and propofol infusion will be used for maintenance of anesthesia

Treatment:

Drug: Anesthesia Agent