Neurotrophic Factors, Tight Junction Proteins, and Cytokines in IBS

Seoul National University

Status: Completed

Conditions: Irritable Bowel Syndrome; Tight Junction Alteration; Pathophysiology

Treatments: Procedure: colonoscopic mucosal biopsy

Study type: Interventional

Funder types: Other

Identifiers

NCT03675100

B-1305/202-003

Details and patient eligibility

About

To evaluate the role of neurotrophic factors (NGF, GDNF, TRPV-1), to quantity tight junction proteins (ZO-1, occludin, claudin) and cytokines (IL-8, TNF-a, IL-1b) in the colonic mucosa of IBS patients and also clarify sex differences in the pathophysiology of IBS.

Enrollment: 100 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Control group Those who were between 18 and 80 years old and did not have any abnormalities in colonoscopy
• Irritable bowel syndrome group Patients who diagnosed as irritable bowel syndrome according to the ROME III criteria

Exclusion criteria

• history of IBD
• abdominal operation
• severe systemic disease
• malignancy,

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

IBS group

Sham Comparator group

Description:

Patients who were diagnosed with IBS according to the ROME III criteria. Colonoscopic mucosal biopsy was undertaken for every subject.

Treatment:

Procedure: colonoscopic mucosal biopsy

Control group

Active Comparator group

Description:

Healthy participants who have no gastrointestinal symptoms and no colonoscopic abnormality. Colonoscopic mucosal biopsy was undertaken for every subject.

Treatment:

Procedure: colonoscopic mucosal biopsy