Neutrophil Extracellular Traps and Sickle Cell Disease

Tel Aviv Sourasky Medical Center

Status: Unknown

Conditions: Sickle Cell Anemia

Study type: Observational

Funder types: Other

Identifiers

NCT02004808

Tasmc-12-RE-0247-CTIL

Details and patient eligibility

About

NETs formation in vaso-occlusive events in sickle cell disease and the role of hydroxyurea treatment.The study hypothesis is that NETs formation by neutrophils has a role in the induction of vaso occlusive disease in blood vessels. It is possible that high leukocyte count in children with sickle cell anemia is a bad prognostic sign due to NETs formation supporting occlusion of peripheral and central blood vessels.Hydroxyurea treatment might prevent vaso occlusive syndrome not only by increasing HbF but also by decreasing neutrophil count and inhibiting NETs formation.

Enrollment: 15 estimated patients

Sex: All

Ages: 1 month to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• children who suffer from sickle cell disease and/or children with sickle cell disease treated with hydroxyurea

Exclusion criteria

• none