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Neutrophil Extracellular Traps and Sickle Cell Disease

T

Tel Aviv Sourasky Medical Center

Status

Unknown

Conditions

Sickle Cell Anemia

Study type

Observational

Funder types

Other

Identifiers

NCT02004808
Tasmc-12-RE-0247-CTIL

Details and patient eligibility

About

NETs formation in vaso-occlusive events in sickle cell disease and the role of hydroxyurea treatment.The study hypothesis is that NETs formation by neutrophils has a role in the induction of vaso occlusive disease in blood vessels. It is possible that high leukocyte count in children with sickle cell anemia is a bad prognostic sign due to NETs formation supporting occlusion of peripheral and central blood vessels.Hydroxyurea treatment might prevent vaso occlusive syndrome not only by increasing HbF but also by decreasing neutrophil count and inhibiting NETs formation.

Enrollment

15 estimated patients

Sex

All

Ages

1 month to 18 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • children who suffer from sickle cell disease and/or children with sickle cell disease treated with hydroxyurea

Exclusion criteria

  • none

Trial contacts and locations

0

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Central trial contact

Ronit Elhasid, MD

Data sourced from clinicaltrials.gov

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