Neutrophil Extracellular Traps Mediate Antiphospholipid Antibody-induced Pregnancy Loss

Shanghai First Maternity and Infant Hospital

Status: Unknown

Conditions: Neutrophil Extracellular Traps; Antiphospholipid Antibody-induced Pregnancy Loss

Study type: Observational

Funder types: Other

Identifiers

NCT03735108

ShanghaiFMIH Shihua Bao

Details and patient eligibility

About

1. Establish a multi-platform detection system for neutrophil extracellular traps in blood and tissues, and evaluate the detection performance;
2. Comparing the expression levels of neutrophil extracellular traps in peripheral blood and decidua of patients with antiphospholipid antibody-induced pregnancy loss and normal control group;
3. Comparing the expression levels of neutrophil extracellular traps in peripheral blood and decidua of mice with antiphospholipid antibody-induced pregnancy loss and normal control group;
4. After treatment of antiphospholipid antibody-induced mouse abortion model with metformin,the effect of metformin on embryo loss rate and viable embryo body weight was observed.

Enrollment: 100 estimated patients

Sex: Female

Ages: 25 to 41 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of Recurrent spontaneous abortion
• Clinical diagnosis of Antiphospholipid syndrome

Exclusion criteria

• Other autoimmune diseases
• Hematopoietic system diseases
• Cardiovascular system diseases
• Gastrointestinal system diseases
• Urinary system diseases
• Nervous system or mental diseases
• Have taken other drugs recently

Trial design

100 participants in 2 patient groups

pregnancy loss group

Description:

the times of pregnancy loss more than or equal to twice

normal control group

Description:

no history of pregnancy loss