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Neutrophil Gelatinase Associated Lipocalin (NGAL) in Urine: Can This Prove to be a Biomarker for Acute Kidney Injury in Patients With Sepsis?

S

Sygehus Lillebaelt

Status

Completed

Conditions

Acute Kidney Injury
Severe Sepsis
Septic Shock

Study type

Observational

Funder types

Other

Identifiers

NCT02034240
DNVK:1305 385

Details and patient eligibility

About

Patients with severe infection and sepsis are in high risk of hypo perfusion and therefore organ affection. Temporary or permanent kidney failure is a common complication in these patients. Today's golden standard for kidney failure detection is creatinine levels rising and / or oliguria. The investigators hypothesize that an even more sensitive biomarker; neutrophil gelatinase associated lipocalin(NGAL) in urine can predict kidney injury before creatinine levels rise. In recent studies NGAL in urine seem to be a sensitive biomarker in these patient to predict kidney injury, but the time factor for sampling optimally is not known. In this pilot study the investigators sample the urine at admission within the first hour of hospitalization to investigate if NGAL can be used as a predictor in an emergency setting.

Enrollment

21 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Severe sepsis
  • Septic shock
  • Patients must not be able to give consent

Exclusion criteria

  • Underaged (18 years )
  • known kidney injury
  • Fully alert patients that can give consent

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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