Neutrophil-lymphocyte and Platelet-lymphocyte Ratios and Their Relations to Vascular Comlications and Glycemic Control in Patients With Type 2 Diabetes Attending The Diabetes Center of Assiut University Hospitals

Assiut University

Status: Not yet enrolling

Conditions: Vascular Complication, Diabetic

Treatments: Radiation: Echocardiogram

Study type: Observational

Funder types: Other

Identifiers

NCT06073756

NLR and PLR and in type 2 DM

Details and patient eligibility

About

Evaluate PLR and NLR and their assiotation to vascular complications and glycemic control in type 2 DM

Full description

Vascular complications of DM result from various disorders including metabolic, cellular, and blood disturbances. Excessive production of pro-inflammatory adipokines from adipose tissue, resulting in low-grade chronic inflammation, causing insulin resistance (IR) and type 2 DM [3]. Hematological changes affecting the red blood cells (RBCs), white blood cells (WBCs), platelet function, and the coagulation factors are detected to be associated with DM . It is important to add that, high WBC count, one of the chief components of inflammatory process, sharing to atheroscle-rosis development and cardiovascular diseases (CVD) . Lately, the neutrophil-to-lymphocyte (N/L) and the platelet-to-lymphocyte (P/L) ratios, were offered as markers of inflammation in cardiac diseases, neoplasms and diabetes-related complications . Moreover, high leucocyte counts have been used as diagnostic and prognostic markers in vascular complication of diabetes

Enrollment: 106 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Type 2 diabetes mellitus (T2DM) patients with good glycemic control and have HBA1C <7and ages ranging from ≥18 old. And poor glycemic control and have HBA1C ≥7 and ages rang from ≥ 18 years old

Exclusion criteria

• Patients with, type 1 diabetes mellitus

  1. Idiopathic thrombocytopenic purpura,
  2. liver cell failure
  3. Myeloproliferative neoplasm
  4. patients on anticoagulant drugs , anti platelet drugs or on steroids were excluded from the study

Trial design

106 participants in 2 patient groups

1

Description:

Type 2 diabetes mellitus (T2DM) patients with good glycemic control and have HBA1C \<7and ages ranging from ≥18 old.

Treatment:

Radiation: Echocardiogram

2

Description:

Type 2 diabetes mellitus (T2DM) patients with poor glycemic control and have HBA1C ≥7 and ages rang from ≥ 18 years old

Treatment:

Radiation: Echocardiogram