Neutrophil to Lymphocyte Ratio and Postdural Headache

Istinye University

Status: Enrolling

Conditions: Preoperative Neutrophil-to-Lymphocyte Ratio (NLR); Postdural Puncture Headache

Treatments: Other: PDPH

Study type: Observational

Funder types: Other

Identifiers

NCT07075874

NLR-PDPH ERKAN

Details and patient eligibility

About

This study will aim to investigate whether systemic inflammatory markers-especially the neutrophil-to-lymphocyte ratio (NLR)-obtained from preoperative complete blood counts can predict the development of post-dural puncture headache (PDPH) in obstetric patients undergoing cesarean section under spinal anesthesia.

Enrollment: 821 estimated patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Women aged 18 years or older
• Underwent elective or emergency cesarean section under spinal anesthesia
• Had complete preoperative complete blood count (CBC) data available
• No known hematological or inflammatory disease
• No intraoperative complications recorded
• Medical records accessible for postoperative follow-up regarding PDPH symptoms

Exclusion criteria

• Age under 18
• Absence of preoperative complete blood count data
• Presence of hematologic malignancy, active infection, autoimmune disease, or immunosuppressive therapy
• Platelet count <150,000/mm³ or INR >1.5
• Incomplete or missing medical records

Trial design

821 participants in 2 patient groups

PDPH Group

Description:

Patients who developed postdural puncture headache (PDPH) following spinal anesthesia for cesarean section.

Treatment:

Other: PDPH

Non-PDPH Group

Description:

Patients who did not develop PDPH after spinal anesthesia for cesarean section

Treatment:

Other: PDPH