Neutrophils to Lymphocytes and Platelets Ratio, Procalcitonin, and Total Leucocytic Count as Indicators of Prognostic Outcome in Septic Patients in the Intensive Care Unit.

Ain Shams University

Status: Enrolling

Conditions: Neutrophils to Lymphocytes; Septic Patients; Procalcitonin; Prognostic Outcome; Total Leucocytic Count; Platelets; Intensive Care Unit

Treatments: Diagnostic Test: Neutrophils to Lymphocytes and Platelets ratio (N/LP)

Study type: Observational

Funder types: Other

Identifiers

NCT07200817

FMASU MD224/2024

Details and patient eligibility

About

This study aims to compare Neutrophil to Lymphocyte and Platelet Ratio, Procalcitonin, and Total Leucocyte Count as indicators of prognostic outcome in septic patients in the intensive care unit.

Full description

Sepsis affects more than 30 million people annually worldwide and is one of the significant causes of death in critical patients worldwide. Any infected person can potentially develop sepsis, and the incidence of sepsis is as high as 1-2% of all hospitalized patients.

Many potential sepsis biomarkers have been proposed, procalcitonin (PCT) and C-reactive protein (CRP) being the most frequently studied.

The ratio of neutrophils to lymphocytes and platelets (N/LP) is a low-cost measure that can be obtained through routine blood tests and is often used to reflect the body's inflammatory state.

Enrollment: 290 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age from 18 to 70 years old.
• Both sexes.
• Septic patients (under the third international consensus definitions of sepsis and septic shock).

Exclusion criteria

• Pregnancy
• Malignancy
• On immunosuppressive therapy
• Hematological Disorders
• Major Trauma
• Major Burns
• Child-Pugh Class C Liver Cirrhosis
• On Hemodialysis

Trial design

290 participants in 1 patient group

Study group

Description:

Septic patients (under the third international consensus definitions of sepsis and septic shock)

Treatment:

Diagnostic Test: Neutrophils to Lymphocytes and Platelets ratio (N/LP)