Nevoid Basal Cell Carcinomas in Gorlin Syndrome

University of Oslo (UIO)

Status: Invitation-only

Conditions: Gorlin Syndrome; Basal Cell Carcinoma

Treatments: Other: Active surveillance

Study type: Observational

Funder types: Other

Identifiers

NCT05898347

487620

Details and patient eligibility

About

The overall aim of the project is to gain knowledge about the expected course of nevoid basal cell carcinomas and the usefulness of dermatoscopy in young individuals with Gorlin syndrome.

Clinical experience and some case-reports suggest that nevoid basal cell carcinomas have an indolent course with slow growth and that they can sometimes regress. However, no systematic research has previously been performed.

Increased knowledge about nevoid basal cell carcinomas and the use of dermatoscopy could be of great clinical value in the follow-up and treatment of individuals with nevoid basal cell carcinoma syndrome.

Enrollment: 10 estimated patients

Sex: All

Ages: 6 to 17 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The individual has Gorlin syndrome (clinically and/or genetically diagnosed)
• The individual is minimum 6 years and maximum 17 years
• The individual has at least three skin lesions clinically compatible with nevoid basal cell carcinomas

Exclusion criteria

• The patient has a psychiatric disorder not compatible with completion of the study examinations
• The patient has received topical treatment (imiquimod, 5-fluorouracil, photodynamic therapy and/or cryotherapy) of nevoid basal cell carcinomas during the last three months

Trial design

10 participants in 1 patient group

Gorlin syndrome

Description:

Children aged six to seventeen years old with Gorlin syndrome and nevoid basal cell carcinomas.

Treatment:

Other: Active surveillance